Dr.ir. I. (Iulian) Apachitei

• Biomaterials
• Surface biofunctionalization of metallic biomaterials
• Medical combination devices
• Implant associated infections
• Antimicrobial surfaces
• Osteoinductive/osteoconductive surfaces
• Drug eluting surfaces
• Dispersion of bioactives
• Orthopaedic cementless implants
• Cardiovascular implants
• Plasma electrolytic oxidation
• Nanocrystalline and nanocomposite coatings

S.A. Yavari, B.S. Necula, L.E. Fratila-Apachitei, J. Duszczyk, I. Apachitei, Biofunctional surfaces by plasma electrolytic oxidation on titanium biomedical alloys, Surface Engineering, (2015), DOI 10.1179/1743294415Y.0000000101

Z. Huan, L.E. Fratila-Apachitei, I. Apachitei, J. Duszczyk, Synthesis and characterization of hybrid micro/nano-structured NiTi surfaces by combination of etching and anodizing, Nanotechnology 25 (2014) 055602 (9pp) doi:10.1088/0957-4484/25/5/055602

Z. Huan, L.E. Fratila-Apachitei, I. Apachitei, J. Duszczyk, Effect of aging treatment on the in vitro nickel release from porous oxide layers on NiTi, Applied Surface Science 274 (2013) 266-272 

B.S. Necula, I. Apachitei, L.E. Fratila-Apachitei, E.J. van Langelaan, J. Duszczyk, Titanium bone implants with superimposed micro/nano-scale porosity and antibacterial capability, Applied Surface Science 273 (2013) 310-314

Z. Huan, L.E. Fratila-Apachitei, I. Apachitei, J. Duszczyk, Porous TiO₂ surface formed on nickel-titanium alloy by plasma electrolytic oxidation: A prospective polymer-free reservoir for drug eluting stent application, Journal of Biomedical Materials Research Part B-Applied Biomaterials 101 (2013) DOI: 10.1002/jbm.b.32872

B.S. Necula, L.E. Fratila-Apachitei, J.P.T.M. van Leeuwen, S.A.J. Zaat, I. Apachitei, J. Duszczyk, Human fetal osteoblast cells viability on porous TiO₂-Ag antibacterial coatings, Acta Biomaterialia 8 (2012) 4191-4197

Z. Huan, L.E. Fratila-Apachitei, I. Apachitei, J. Duszczyk, Characterization of porous TiO₂ surface formed on 316L stainless steel by plasma electrolytic oxidation for stents applications, Journal of Functional Biomaterials 3 (2012) 349-360

G.J.S. Dawes, L.E. Fratila-Apachitei, B.S. Necula, I. Apachitei, J.P.T.M. van Leeuwen, J. Duszczyk and M. Eijken, Effects of dexamethasone-loaded PLGA microspheres on human fetal osteoblasts, Journal of Biomaterials Applications 27 (2012) 477-483

Z. Huan, L.E. Fratila-Apachitei, I. Apachitei, J. Duszczyk, Porous NiTi surfaces for biomedical applications, Applied Surface Science 258 (2012) 5244-5249

A. Leoni, I. Apachitei, A.C. Riemslag, L.E. Fratila-Apachitei, J. Duszczyk, In vitro fatigue behavior of surface oxidized Ti35Zr10Nb biomedical alloy, Materials Science and Engineering C: Materials for Biological Applications 31 (2011) 1779-1783

B.S. Necula, I. Apachitei, F.D. Tichelaar, L.E. Fratila-Apachitei, J. Duszczyk, An electron microscopical study on the growth of TiO₂-Ag antibacterial coatings on Ti6Al7Nb biomedical alloy, Acta Biomaterialia 7 (2011) 2751-2757

I. Apachitei, A. Leoni, A.C. Riemslag, L.E. Fratila-Apachitei, J. Duszczyk, Enhanced fatigue performance of porous coated Ti6Al4V biomedical alloy, Applied Surface Science 257 (2011) 6941-6944

K. Mulia, G.J. Witkamp, G.J.S. Dawes, L.E. Fratila-Apachitei, I. Apachitei, J. Duszczyk, H. Pellikaan, Drug release from PLGA microspheres attached to solids using supercritical CO₂, Journal of Biomaterials Applications 25 (2011) 401-412

M.S. Kerremans, E.J. van Langelaan, I. Apachitei, Vermoeidheidsfractuur van de helical blade van een Proximal Femoral Nail Antirotation, Nederlands Tijdschrift voor Orthopaedie, Vol. 17, No 3, September (2010) 117-121

G.J.S. Dawes, L.E. Fratila-Apachitei, B.S. Necula, I. Apachitei, G.J. Witkamp, J. Duszczyk, Release of PLGA-encapsulated dexamethasone from microsphere coated porous surfaces, Journal of Material Science: Materials in Medicine 21 (2010) 215-221

B.S. Necula, L.E. Fratila-Apachitei, S.A.J. Zaat, I. Apachitei, J. Duszczyk, In vitro antibacterial activity of porous TiO₂-nanoAg composite coatings against methicillin resistant S. aureus, Acta Biomaterialia 5 (2009) 3573-3580

I. Apachitei, B. Lonyuk, L.E. Fratila-Apachitei, J. Zhou, J. Duszczyk, Fatigue response of porous coated titanium biomedical alloys, Scripta Materialia 61 (2009) 113-116

G.J.S. Dawes, L.E. Fratila-Apachitei, K. Mulia, I. Apachitei, G.-J. Witkamp, J. Duszczyk, Size effect of PLGA spheres on drug loading efficiency and release profiles,Journal of Materials Science: Materials in Medicine 20 (2009) 1089-1094

Research facilities