Vacancies

PostDoc: Sub-cellular biopsy: a key technology to gather fundamental knowledge for effective cancer therapy

We are looking for two self-motivated postdocs with a strong interest in working in a flagship multidisciplinary project between Erasmus MC and TU Delft on sub-cellular biopsy, supported by the Convergence initiative. The goal of this project is to enter the nucleus of cells using microfluidic atomic force microscopy cantilevers and to extract temporally formed organelles involved in repair of DNA damage for subsequent analysis by cryo-EM and mass spectrometry. One aspect of the project involves fabrication of the cantilevers to be used to interrogate individual cells by harvesting the sub-cellular organelles and their components. Another aspect is the generation by genomic engineering of appropriate cell lines expressing fluorescent DNA repair proteins in different genetic backgrounds to dissect distinct steps in DNA repair. The project will be executed in a multi-disciplinary team from Erasmus MC and TU Delft consisting of experts in Molecular Genetics, Cell Biology, (Bio)mechanical Engineering, Microfabrication, Instrumentation, Electron Microscopy and Mass Spectrometry.

For more information and how to apply please check out the full ad.

Postdoc Numerical and Experimental Contact and Soil Mechanics

Current offshore monopile installation, using hydraulic hammers, creates significant underwater noise which in turn requires the use of noise mitigation measures. Furthermore, the aggressive blow of a hydraulic hammer potentially results in fatigue damage and prevents secondary steel to be welded to the pile. It has been demonstrated that the BLUE Piling Technology, which uses longer impact pulses to the pile head, significantly reduces the monopiles' installation noise and operational savings.

In this project, which is a collaborative between IHC IQIP and TU Delft, the main goal is to simulate the behavior of BLUE Piling Technology in order to better understand and predict the drivability of assembled monopiles.

The post-doctoral researcher will advance the knowledge of the interaction between impact hammer, monopile, and soil during the installation of large offshore monopiles. Scientific challenges exist in the fundamental understanding of the dynamic interaction between various components, and its effect on optimized energy transfer without generation of excessive noise during pile driving.The tasks to be performed include:

  • Create a computational model of the BLUE Piling technology that is capable of accurately predicting the behavior of a long pulse along the monopile. Such model will need to account for the interaction between the monopile and soil.
  • Participate actively in the validation of the computational model via experiments. To that end, the researcher will conceptualize, design, and supervise the construction of a novel impact pile driver for a geotechnical centrifuge. The developed hammer will be capable of applying controlled impact pulses with designed amplitude, duration, and frequencies. The work will include implementation of advanced instrumentation for experimental studies. The design and execution of the project will be in close collaboration with a team of researchers at the Civil Engineering faculty of TU Delft and industry experts.
  • Requirements

  • Candidates will meet as many of the following requirements as possible:

  • PhD degree in Mechanical Engineering or a related discipline with a strong background in mechatronics and computational mechanics;
  • Can handle experimental work such as driving servo motion systems and system level design;
  • Knowledge of geotechnical centrifuge modelling, foundation engineering, and offshore foundations is highly appreciated;
  • Knowledge on finite element methods (FEM) and FEM software commonly used in industry/academia (Abaqus, Ansys, Comsol) is highly appreciated;
  • Interest in contributing to the global success of the project, liaising with other team members responsible for different segments of the research;
  • Appreciation of team work, good social skills, and ability to function in international circles involving experts from academia and industry;
  • High proficiency in spoken/written English, and proven experience in preparing technical publications and project reports;
  • Interest in contributing to the co-supervision of MSc graduation projects.

Salary indication: €3.491-€4.402.
Interested? check out the full ad and how to apply here.

PhD in Physics/Applied Physics/Mechanical Engineering/Biomechanical Engineering/Micro-Nanotechnology

We are looking for two self-motivated postdocs with a strong interest in working in a flagship multidisciplinary project between Erasmus MC and TU Delft on sub-cellular biopsy, supported by the Convergence initiative. The goal of this project is to enter the nucleus of cells using microfluidic atomic force microscopy cantilevers and to extract temporally formed organelles involved in repair of DNA damage for subsequent analysis by cryo-EM and mass spectrometry. One aspect of the project involves fabrication of the cantilevers to be used to interrogate individual cells by harvesting the sub-cellular organelles and their components. Another aspect is the generation by genomic engineering of appropriate cell lines expressing fluorescent DNA repair proteins in different genetic backgrounds to dissect distinct steps in DNA repair. The project will be executed in a multi-disciplinary team from Erasmus MC and TU Delft consisting of experts in Molecular Genetics, Cell Biology, (Bio)mechanical Engineering, Microfabrication, Instrumentation, Electron Microscopy and Mass Spectrometry.

Skills desired

  • Atomic force microscopy
  • Microfluidics
  • Microfabrication
  • Biomechanical characterization
  • Building measurement schemes for micro-nanoscale devices
  • Characterization methods like SEM, TEM, mass spectrometry
  • Collaborative and team player


Expectations 

The postdocs should have a deep interest in the convergence of health sciences, physical sciences, and engineering to foster individual health and keep the healthcare system sustainable. They will work closely with the supervisors, Principal investigators and Collaborating investigators of the project to conduct high calibre research. They are also encouraged to initiate and lead collaborative work with other postdocs within the Convergence for health(care) initiative. Salary will be commensurate with qualification and experience.

Recruitment takes place until the vacancy is filled.

Contact information

Prof. Roland Kanaar
Erasmus MC
r.kanaar@erasmusmc.nl
Murali Ghatkesar
TU Delft
m.k.ghatkesar@tudelft.nl

Apply for this position

PhD in Molecular Biology/Biochemistry

We are looking for two self-motivated postdocs with a strong interest in working in a flagship multidisciplinary project between Erasmus MC and TU Delft on sub-cellular biopsy, supported by the Convergence initiative. The goal of this project is to enter the nucleus of cells using microfluidic atomic force microscopy cantilevers and to extract temporally formed organelles involved in repair of DNA damage for subsequent analysis by cryo-EM and mass spectrometry. One aspect of the project involves fabrication of the cantilevers to be used to interrogate individual cells by harvesting the sub-cellular organelles and their components. Another aspect is the generation by genomic engineering of appropriate cell lines expressing fluorescent DNA repair proteins in different genetic backgrounds to dissect distinct steps in DNA repair. The project will be executed in a multi-disciplinary team from Erasmus MC and TU Delft consisting of experts in Molecular Genetics, Cell Biology, (Bio)mechanical Engineering, Microfabrication, Instrumentation, Electron Microscopy and Mass Spectrometry.

Skills desired

  • Recombinant DNA techniques
  • Tissue culture
  • Live cell fluorescent microscopy
  • Mass spectrometry analysis
  • Collaborative and team player


Expectations 

The postdocs should have a deep interest in the convergence of health sciences, physical sciences, and engineering to foster individual health and keep the healthcare system sustainable. They will work closely with the supervisors, Principal investigators and Collaborating investigators of the project to conduct high calibre research. They are also encouraged to initiate and lead collaborative work with other postdocs within the Convergence for health(care) initiative. Salary will be commensurate with qualification and experience.

Recruitment takes place until the vacancy is filled.

Contact information

Prof. Roland Kanaar
Erasmus MC
r.kanaar@erasmusmc.nl
Murali Ghatkesar
TU Delft
m.k.ghatkesar@tudelft.nl

Apply for this position