Vacancies

PostDoc: Sub-cellular biopsy: a key technology to gather fundamental knowledge for effective cancer therapy

We are looking for two self-motivated postdocs with a strong interest in working in a flagship multidisciplinary project between Erasmus MC and TU Delft on sub-cellular biopsy, supported by the Convergence initiative. The goal of this project is to enter the nucleus of cells using microfluidic atomic force microscopy cantilevers and to extract temporally formed organelles involved in repair of DNA damage for subsequent analysis by cryo-EM and mass spectrometry. One aspect of the project involves fabrication of the cantilevers to be used to interrogate individual cells by harvesting the sub-cellular organelles and their components. Another aspect is the generation by genomic engineering of appropriate cell lines expressing fluorescent DNA repair proteins in different genetic backgrounds to dissect distinct steps in DNA repair. The project will be executed in a multi-disciplinary team from Erasmus MC and TU Delft consisting of experts in Molecular Genetics, Cell Biology, (Bio)mechanical Engineering, Microfabrication, Instrumentation, Electron Microscopy and Mass Spectrometry.

For more information and how to apply please check out the full ad.

Postdoc Origami Nanophotonics Using Machine Learning for Space Imaging & Exploration

Nanophotonic is now becoming the next pillar for a large array from applications from world-class sensors to space exploration. Machine learning techniques can help to guide the design process of the next generation of nanophotonics devices.

At the TU Delft, we developed some of the world’s thinnest mirrors using membranes with a thickness about 1/1000th the diameter of human hair. These ultra-thin membranes can be converted into highly reflective mirrors by patterning the membranes with nanoscale holes. By designing the size of the nanoscale holes and spacing between them, one can design these membranes to reflect at any desired wavelength. This nanoscale engineering of materials allow us to design and create meta-materials with properties which are not found in nature.These type of nanoscale mirrors are now having a significant impact in a number of fields including imaging, space exploration, and sensing. We will be designing a new type of mirror that uses concepts from origami and machine learning to give such nanoscale reflectors a competely new edge in performance.

The goal of this project is to merge the know-how of nanophotonics fabrication with machine learning algorithms to create origami structures from thin films. Our data-driven algorithm allows us to create designs that would be unintuitive for human-based designs.

In this project you would be in charge of designing new types of nanophotonic reflector, manufacturing such nanophotonics on microchips using state-of-the-art cleanroom facilities and testing machine learning designs using laser optics laboratories. You would be working in collaboration with Dr. Richard Norte's lab and Dr. Miguel Bessa's lab which aim to put together their expertise to mold new ideas in nanotechnology.

Interested? We invite you to apply by clicking this link for the full ad and how to apply.

PhD in Physics/Applied Physics/Mechanical Engineering/Biomechanical Engineering/Micro-Nanotechnology

We are looking for two self-motivated postdocs with a strong interest in working in a flagship multidisciplinary project between Erasmus MC and TU Delft on sub-cellular biopsy, supported by the Convergence initiative. The goal of this project is to enter the nucleus of cells using microfluidic atomic force microscopy cantilevers and to extract temporally formed organelles involved in repair of DNA damage for subsequent analysis by cryo-EM and mass spectrometry. One aspect of the project involves fabrication of the cantilevers to be used to interrogate individual cells by harvesting the sub-cellular organelles and their components. Another aspect is the generation by genomic engineering of appropriate cell lines expressing fluorescent DNA repair proteins in different genetic backgrounds to dissect distinct steps in DNA repair. The project will be executed in a multi-disciplinary team from Erasmus MC and TU Delft consisting of experts in Molecular Genetics, Cell Biology, (Bio)mechanical Engineering, Microfabrication, Instrumentation, Electron Microscopy and Mass Spectrometry.

Skills desired

  • Atomic force microscopy
  • Microfluidics
  • Microfabrication
  • Biomechanical characterization
  • Building measurement schemes for micro-nanoscale devices
  • Characterization methods like SEM, TEM, mass spectrometry
  • Collaborative and team player


Expectations 

The postdocs should have a deep interest in the convergence of health sciences, physical sciences, and engineering to foster individual health and keep the healthcare system sustainable. They will work closely with the supervisors, Principal investigators and Collaborating investigators of the project to conduct high calibre research. They are also encouraged to initiate and lead collaborative work with other postdocs within the Convergence for health(care) initiative. Salary will be commensurate with qualification and experience.

Recruitment takes place until the vacancy is filled.

Contact information

Prof. Roland Kanaar
Erasmus MC
r.kanaar@erasmusmc.nl
Murali Ghatkesar
TU Delft
m.k.ghatkesar@tudelft.nl

Apply for this position

PhD in Molecular Biology/Biochemistry

We are looking for two self-motivated postdocs with a strong interest in working in a flagship multidisciplinary project between Erasmus MC and TU Delft on sub-cellular biopsy, supported by the Convergence initiative. The goal of this project is to enter the nucleus of cells using microfluidic atomic force microscopy cantilevers and to extract temporally formed organelles involved in repair of DNA damage for subsequent analysis by cryo-EM and mass spectrometry. One aspect of the project involves fabrication of the cantilevers to be used to interrogate individual cells by harvesting the sub-cellular organelles and their components. Another aspect is the generation by genomic engineering of appropriate cell lines expressing fluorescent DNA repair proteins in different genetic backgrounds to dissect distinct steps in DNA repair. The project will be executed in a multi-disciplinary team from Erasmus MC and TU Delft consisting of experts in Molecular Genetics, Cell Biology, (Bio)mechanical Engineering, Microfabrication, Instrumentation, Electron Microscopy and Mass Spectrometry.

Skills desired

  • Recombinant DNA techniques
  • Tissue culture
  • Live cell fluorescent microscopy
  • Mass spectrometry analysis
  • Collaborative and team player


Expectations 

The postdocs should have a deep interest in the convergence of health sciences, physical sciences, and engineering to foster individual health and keep the healthcare system sustainable. They will work closely with the supervisors, Principal investigators and Collaborating investigators of the project to conduct high calibre research. They are also encouraged to initiate and lead collaborative work with other postdocs within the Convergence for health(care) initiative. Salary will be commensurate with qualification and experience.

Recruitment takes place until the vacancy is filled.

Contact information

Prof. Roland Kanaar
Erasmus MC
r.kanaar@erasmusmc.nl
Murali Ghatkesar
TU Delft
m.k.ghatkesar@tudelft.nl

Apply for this position