particle manipulation in a microfluidic device

Particle manipulation using sources/sinks in a microfluidic device

Description:
New ways of manipulating particles, droplets and cells in microfluidic devices have been extensively investigated and developed. This is driven owing to their applications in several fields of engineering such as medical diagnostics, chemical industry, drug delivery, etc. At the Aero & Hydrodynamics lab we are developing the method to manipulate the particles using sources and sink of bulk fluid to make virtual boundaries which can be used for chromatography, focussing, filtering, concentration, trapping, detecting, sorting, etc. Work from previous master student showed the versatility of the device from just 4 holes which could be used as source or sink. [1]

Objective:
Increasing the number of holes from 4 and doing particle manipulation experiment on PDMS micro device (72 x 24 x 0.25 mm) using pressure driven flow.

Approach:
The student will first work on the simpler plexi-glass based micro device to get used to experiment setup and its complexities. PIV and PTV will be used to measure the flow field and track the particle trajectory in the device respectively.

Outcome:
By the end of the thesis, we expect to have a device which is capable of manipulating particles and can generate various types of virtual boundaries (The only limit is your imagination). Possibility of writing a journal paper.

 

References:

[1] Deka, A., Manipulation of particles in a Hele-Shaw cell using sources and sinks

[2] Adrian, R. and J. Westerweel (2010). Particle image velocimetry. Cambridge University Press.

Black circles show the location of the holes which can be used as source/sink

M.Sc. project in microfluidics

Chair:
Fluid Mechanics

Involved People:
Ankur Kislaya, M.Sc.
dr. Daniel Tam
prof.dr.ir. J. Westerweel