The Department of Bionanoscience focuses on the fundamental understanding of biological processes, from the level of single molecules to the full complexity of living cells. This research provides fascinating insight in the molecular mechanisms that lead to cellular function. Furthermore it enables the in vitro bottom-up construction of cellular machinery and it impacts applications ranging from biomolecular diagnostics to novel antibiotics and targeted nanomedicine. The department features a strongly multidisciplinary and international team of scientists, whose research areas include single-molecule biophysics, synthetic biology, as well as (quantitative) cell biology.
Researchers build DNA replication in a model synthetic cell
Researchers at Delft University of Technology, in collaboration with colleagues at the Autonomous University of Madrid, have created an artificial DNA blueprint for the replication of DNA in a cell-like structure.
Loops, loops, and more loops: This is how your DNA gets organised
Researchers from the Kavli Institute of Delft University and EMBL Heidelberg now managed for the first time to isolate and film and witnessed—in real time—how a single protein complex called condensin reels in DNA to extrude a loop.