Research
Research interests
The current main research interests of the Paul group are towards exploring the synthetic potential of Nature's catalysts. Research focus include designing nicotinamide coenzyme biomimetics (NCBs) for oxidoreductases, and an emphasis on the development of non-natural enzymatic reactions for applications in organic chemistry.
Research projects include:
- Investigating light-driven sustainable biocatalysis H2020-MSCA-ITN-EJD PhotoBioCat
- Engineering biomimetic cofactors (nicotinamide, flavin and SAM)
- Exploring the synthetic potential of flavoprotein reductases and monooxygenases
- Developing enzymatic cascades
- Enzyme discovery for reductases within the Zero Emission Biotechnology Programme
Selected work on biomimetic cofactors:
- Chem. Commun. 2022, 58, 10540, 10.1039/d2cc02411j
- Catal. Sci. Technol. 2021, 11, 5077, 10.1039/D1CY00855B
- ChemCatChem 2020, 12, 1368–1375, 10.1002/cctc.201902044
- Curr. Opin. Biotechnol. 2019, 60, 63–71, 10.1016/j.copbio.2019.01.001 Review
- Catalysts 2019, 9, 207, 10.3390/catal9030207
- ACS Catal. 2019, 9, 1389–1395, 10.1021/acscatal.8b04500
- Angew. Chem. Int. Ed. 2018, 57, 13825–13828, 10.1002/anie.201804409
- Catalysts 2017, 7, 130, 10.3390/catal7050130
- Appl. Microbiol. Biotechnol., 2016, 100, 4773–4778, 10.1007/s00253-016-7500-1 Review
- J. Am. Chem. Soc. 2016, 138, 11089–11092, 10.1021/jacs.6b05625
- J. Am. Chem. Soc. 2016, 138, 1303–1309, 10.1021/jacs.5b12252
- ACS Catal. 2015, 5, 2961–2965, 10.1021/acscatal.5b00041
- ACS Catal. 2014, 4, 788–797, 10.1021/cs4011056 Review
- Org. Lett. 2013, 15, 180–183, 10.1021/ol303240a
Selected work on enzymatic cascades:
- ACS Catal. 2022, 12, 1111, 10.1021/acscatal.1c05334
- ChemCatChem 2021, 14, e202101576, 10.1002/cctc.202101576
- Curr. Opin. Green Sustain. Chem. 2021, 32, 100548, 10.1016/j.cogsc.2021.100548 Review
- Catal. Sci. Technol. 2021, 11, 5077, 10.1039/D1CY00855B
Funding
