Research

Metabolism is the ‘engine’ of microbial live, generating energy and redox equivalents but also precursors for growth. Its sustained operation by large networks of enzymatic reactions forms a complex network that requires fine-tuned regulation. Malfunction of the regulation can lead to accumulation of intermediates and loss of function and decreased fitness (or even death). The network stoichiometry has been studied intensively including the use of metabolic tracer experiments to quantify steady-state fluxes of the network. Identifying the underlying kinetics and understanding the regulatory mechanism of metabolism is the aim of the Wahl group. These insights are then used to design microbial cell factories that operate robust under industrial conditions.

Current projects

Teaching

The courses I teach cover different aspects of the Life Science and Technology (LST) curriculum as well as post master education (Biotechnology Academy Delft)

I believe that following elements are indispensable for an effective and fun course

  • Clear and transparent structure of the content and the grading scheme
  • Elements of competition
  • Early and sufficient feedback on student activities
  • Appreciate and motivate student activity

The content has to stimulate thinking and challenge students. Therefore relevant and challenging assignments are central in my courses. I use group-work to stimulate peer learning. Extensive support and feedback are used to further improve the quality.

For the preparation, communication and execution of course concepts, gamification is applied. The concept values all student’s activities and motivates for active participation. A list of current courses can be found under ‘Teaching’.

Collaboration Partners

  • Dr. Stephan Noack, Dr. Marco Oldiges and Dr. Kathrina Nöh Forschungszentrum Jülich GmbH, Germany
  • Dr. Isabel Rocha University of Minho, Portugal
  • Prof. Bas Teusink (since 2010) VU Amsterdam, The Netherlands
  • Prof. Pau Ferrer, Universidad Autonoma de Barcelona, Spain
  • Prof. M. Canovas, Universidad de Murcia, Spain
  • Dr. C. Danelon, Dr. G. Bokinsky, BioNano TU Delft

Editorial board memberships

Since 2010 Applied and Environmental Microbiology
Since 2016 Scientific Reports

Aljoscha Wahl

Assistant Professor


PhD Leonor Guedes da Silva

Leonor Guedes da Silva successfully defended her PhD thesis: "Life in changing environments: The intriguing cycles of polyphosphate Accumulating organisms". A systems biology study including lots of lab work & computational approaches to connect the genotype to phenotype of environmentally-relevant microorganisms. Read the book <a href="https://repository.tudelft.nl/islandora/object/uuid%3A944a1cc2-9a30-4b84-91b9-5022d689d7f3?collection=research"> here</a>

Eleni Vasilakou defends her PhD

Dr. Eleni Vasilakou successfully defended her PhD Escherichia coli metabolism under dynamic conditions: The tales of substrate hunting. CONGRATULATIONS!

Mariana Itzel Velasco wins poster prize at ISBP 2018

Mariana Itzel Velasco has won a poster prize at ISBP 2018 in Beijing with her contribution "Coupling Catabolism and Poly-3-Hydroxybutyrate Production in Escherichia coli"

Congratulations!!

Dr. Robin Schumacher successfully defends his PhD thesis

Robin Schumacher (now at A*star institute Singapore) successfully defended his PhD thesis "Metabolic trade-offs arising from increased free energy conservation in Saccharomyces cerevisiae" (available online here). The defense took place 16-10-2018 at aula.