The department of Imaging Physics develops novel instrumentation and imaging technologies. We are driven by our scientific curiosity and problem oriented nature in research with a strong connection to industry and to educate future leaders in the field of imaging science.
The scientific staff of the department is formed by independent Principle Investigators or Educators.
15 May 2017
Photonics Event 2017
Photonics has been defined as the key enabling technology for the 21st century, improving industries’ businesses and becoming more competitive on al global scale. The Photonics Event is an exhibition addressing different photonics technologies and different industries where these technologies are applied. This event will be held in Veldhoven on June 14th.
15 May 2017
Wiro Niessen elected as member of KNAW
Wiro Niessen, Professor of Biomedical Imaging one of 26 new members appointed by the Royal Netherlands Academy of Arts and Sciences (KNAW). The Academy has approximately 550 members across all scientific disciplines. These leading scientists are elected on the basis of their scientific achievements. Members are appointed for life. The new Academy members will be installed on Thursday 8 June.
05 April 2022
Optimal transfer functions for bandwidth-limited imaging
A paper is out in Physical Review Research by a collaboration between Sjoerd Stallinga and researchers in Grenoble and Gottingen on the question what the best possible transfer function is for a band-limited imaging system such as fluorescence based microscopes.
29 March 2022
Koen Jurgens joined ImPhys as MSc student
Koen Jurgens is a Molecular and Cellular Life Sciences Msc student from Utrecht University, track Biophysics & Molecular Imaging. He will 3D print phase plates to engineer the point spread function, and consecutively evaluate the performances to optimize the design of these phase plates. His supervisor is Bernd Rieger.
From light spots to supersharp images
Making detailed 3D images of proteins in living cells with a special light microscope, without damaging those cells. That is what Sjoerd Stallinga, winner of an ERC Advanced grant worth 2.3 million euros, wants to achieve. In order to do so he is going to scan samples nanometer by nanometer using a sophisticated 3D light pattern in an approach that requires extensive collaboration between different disciplines.
Spotlight on aggressive cancer cells
Metastases in cancer are often caused by a few abnormal cells. These behave more aggressively than the other cancer cells in a tumour. Miao-Ping Chien and Daan Brinks are working together, from two different universities, on a method to detect these cells. Their research has now been published in Nature Biomedical Engineering
How to find structurally different molecules before they disappear in the average?
Particle fusion for single molecule localization microscopy improves signal-to-noise ratio and overcomes underlabeling, but ignores structural heterogeneity or conformational variability. This study presents a-priori knowledge-free unsupervised classification of structurally different particles employing the Bhattacharya cost function as dissimilarity metric.
The impact of noise on Structured Illumination Microscopy image reconstructions
Super-resolution structured illumination microscopy (SIM) has become a widely used method for biological imaging. Standard reconstruction algorithms, however, are prone to generate noise-specific artifacts that limit their applicability for lower signal-to-noise data. Here we present a physically realistic noise model that explains the structured noise artifact, which we then use to motivate new complementary reconstruction approaches.
A new tool to understand the brain
How does our brain work? An international team of researchers, including lead author Daan Brinks of TU Delft, has taken another step towards answering that question. They have created a new tool that allows them to image electrical signals in brains with an unprecedented combination of precision, resolution, sensitivity, and depth.
Researchers make 3D image with light microscope
For the first time, Delft researchers have succeeded in making a three-dimensional image of a cellular component using light. The component in question is the nuclear pore complex: tunnels that facilitate traffic to and from the cell nucleus. Studying cell components in 3D can help to determine the cause of various diseases, among other things. The researchers have published their findings in Nature Communications.
Decoding movement intentions in the brain using ultrasound waves
While many techniques can image brain activity, this was the first time that a new technology, called functional ultrasound imaging, was used to detect motor planning deep within the brain. The team is now applying functional ultrasound decoding to more complicated motor control tasks. At ImPhys, Dr. Maresca is developing ultrasound technologies to image brain activity down to the cellular scale.