The section Biomedical Imaging (BI) develops new technologies and complete imaging systems that enable to make 3D and 4D images of distributions of molecules, specific cells and electron density of tissues in living beings. These systems allow to non-invasively assess anatomy, physiology and pathology in organs and tumors with world record spatiotemporal resolution and sensitivity, and with unique capabilities for theranostic and multi-tracer imaging. This gives many new opportunities to develop new pharmaceuticals and biomarkers for treatment and diagnosis of e.g. cancer, diabetes, skeleton, brain and cardiac diseases. In collaboration with industrial partners such as MILabs, the group has been highly successful in developing very high resolution Single Photon Emission Computed Tomography (SPECT), Positron Emission Tomography (PET), Optical Imaging (OI) and X-ray Computed Tomography (CT) modules. Today, several of these are incorporated in multi-modal imaging platforms applied to imaging of animals, tissue samples or materials. We are currently applying our expertise to develop clinical SPECT scanners with unsurpassed resolution and detection sensitivity.
Scans made with scanners developed in our group. Top: Mouse SPECT=PET-CT with 4 different isotopes (P.E.B. Vaissier et al, Integration of small animal SPECT and PET with other imaging modalities, TvNG 2013). Bottom: Beating mouse heart (4D in vivo Molecular Microscopy of the Mouse Heart, N. Befera, C. Badea & G. Johnson, Center for in vivo Microscopy, Duke University).