Publications

M.E. Klijn, J. Hubbuch

Application of ultraviolet, visible, and infrared light imaging in protein-based biopharmaceutical formulation characterization and development studies 
European Journal of Pharmaceutics and Biopharmaceutics; 2021

https://doi.org/10.1016/j.ejpb.2021.05.013

M.E. Klijn, J. Hubbuch

Influence of image analysis strategy, cooling rate, and sample volume on apparent protein cloud-point temperature determination 
Bioprocess and Biosystems Engineering; 2020

https://doi.org/10.1007/s00449-020-02465-8

M.E. Klijn, J. Hubbuch

Time-dependent multi-light source image classification combined with automated multidimensional protein phase diagram construction for protein phase behavior analysis
Journal of Pharmaceutical Sciences; 2020; 109 (1);331-339

https://doi.org/10.1016/j.xphs.2019.07.017

M.E. Klijn1, A.K. Wöll1, J. Hubbuch

Apparent protein cloud point temperature determination using a low volume high-throughput cryogenic device in combination with automated imaging 
Bioprocess and Biosystems Engineering; 2019

; 43; p. 439-456

doi.org/10.1007/s00449-019-02239-x

 

1) Contributed equally

M.E. Klijn, J. Hubbuch

Redesigning food protein formulations with empirical phase diagrams: A case study on glycerol-poor and glycerol-free formulations
Food Research International; 2019; 125; p.108609

https://doi.org/10.1016/j.foodres.2019.108609

M.E. Klijn1, P. Vormittag1, N. Bluthardt, J. Hubbuch 

High-throughput computational pipeline for 3-D structure preparation and in silico protein surface property screening: A case study on HBcAg dimer structures 
International Journal of Pharmaceutics; 2019; 563; p. 337-346

https://doi.org/10.1016/j.ijpharm.2019.03.057

1) Contributed equally

M.E. Klijn, J. Hubbuch

Correlating multidimensional short-term empirical protein properties to long-term protein physical stability data via empirical phase diagrams
International Journal of Pharmaceutics; 2019; 560; p. 166-174

https://doi.org/10.1016/j.ijpharm.2019.02.006

M.E. Klijn, J. Hubbuch

Application of empirical phase diagrams for multidimensional data visualization of high-throughput microbatch crystallization experiments
Journal of Pharmaceutical Sciences; 2018; 107 (8); p. 2063 - 2069

https://doi.org/10.1016/j.xphs.2018.04.018