Coating of Pharmaceutical powders
Pharmaceutical powders (in form of micro/nano-particles) can be coated in large quantities via techniques such as atomic layer deposition (ALD) or molecular layer deposition (MLD) in the gas phase. Their surface properties can be fine-tuned for various application. The coating thickness can be adjusted to achieve in vitro improved stability or controlled release of the coated drug substance. The surface chemistry (hydrophilicity/hydrophobicity and charge) can be adjusted aiming at in vivo enhanced penetration in mucus or improved endocytosis by targeted cells.
My current project will focus on coating of pharmaceutical powders using atomic layer deposition and unravelling the underlying drug dissolution mechanism and the influence of surface modifications of pharmaceutical powders on their interaction with mucus/cells.