The department of Imaging Physics develops novel instrumentation and imaging technologies. We are driven by our scientific curiosity and problem oriented nature in research with a strong connection to industry and to educate future leaders in the field of imaging science.
The scientific staff of the department is formed by independent Principle Investigators or Educators.
07 november 2016
Optics Group on Engineers Online with "Inkless printing spin off"
Unfortunately the article is only available in Dutch. For more information, please contact Aurele Adam. Inkless, een spin-off van de TU Delft, heeft het zwart/wit printen zonder inkt onder de knie, zonder dat de prints aan kwaliteit inboeten. "Bij onze methode, die we samen met de Optics Research Group van de TU Delft hebben ontwikkeld, carboniseren we het papier", vertelt mede-oprichter Arnaud van der Veen. "Als je dat zarboniseren op een normale manier met een dun materiaal als papier probeert, brand je al snel door het papier heen. Ook is de print in dat geval niet permanent en onvoldoende zwart. Inkless heeft een veel betere controle over het carbonisatieproces waardoor we minder diep hoeven te printen en dus niet door het papier heen gaan. We hebben ook een oplossing ontwikkeld die er voor zorgt dat de print voldoende zwart is en tevens permanent." De technologie is vastgelegd in diverse patenten.
01 november 2016
Work in progress: Realisation of the VLLAIR Lab
The building activities for our new VLLAIR lab (D1-Wing ground floor) have been started. Gradually the demolition dust has been settled and the outlines of the lab are appearing. Please find below a “sneak preview” of the lab.
26 april 2022
ERC Advanced grant for Sjoerd Stallinga
The European Research Council has awarded an ERC Advanced Grant to Sjoerd Stallinga The European grant enables internationally established research leaders to conduct a five-year research project.
26 april 2022
Octoscope: a compact microscope for voltage imaging
Voltage imaging and optogenetics offer new routes to optically detect and influence neural dynamics. Optimized hardware is necessary to make the most of these new techniques. In this study the Octoscope, a versatile, multimodal device for all-optical electrophysiology is presented. The researchers illustrate its concept and design and demonstrate its capability to perform both 1-photon and 2-photon voltage imaging with spatial and temporal light patterning, in both inverted and upright configurations, in vitro and in vivo.
In the spotlight
In the spotlight
From light spots to supersharp images
Making detailed 3D images of proteins in living cells with a special light microscope, without damaging those cells. That is what Sjoerd Stallinga, winner of an ERC Advanced grant worth 2.3 million euros, wants to achieve. In order to do so he is going to scan samples nanometer by nanometer using a sophisticated 3D light pattern in an approach that requires extensive collaboration between different disciplines.
Spotlight on aggressive cancer cells
Metastases in cancer are often caused by a few abnormal cells. These behave more aggressively than the other cancer cells in a tumour. Miao-Ping Chien and Daan Brinks are working together, from two different universities, on a method to detect these cells. Their research has now been published in Nature Biomedical Engineering
How to find structurally different molecules before they disappear in the average?
Particle fusion for single molecule localization microscopy improves signal-to-noise ratio and overcomes underlabeling, but ignores structural heterogeneity or conformational variability. This study presents a-priori knowledge-free unsupervised classification of structurally different particles employing the Bhattacharya cost function as dissimilarity metric.
The impact of noise on Structured Illumination Microscopy image reconstructions
Super-resolution structured illumination microscopy (SIM) has become a widely used method for biological imaging. Standard reconstruction algorithms, however, are prone to generate noise-specific artifacts that limit their applicability for lower signal-to-noise data. Here we present a physically realistic noise model that explains the structured noise artifact, which we then use to motivate new complementary reconstruction approaches.
A new tool to understand the brain
How does our brain work? An international team of researchers, including lead author Daan Brinks of TU Delft, has taken another step towards answering that question. They have created a new tool that allows them to image electrical signals in brains with an unprecedented combination of precision, resolution, sensitivity, and depth.
Researchers make 3D image with light microscope
For the first time, Delft researchers have succeeded in making a three-dimensional image of a cellular component using light. The component in question is the nuclear pore complex: tunnels that facilitate traffic to and from the cell nucleus. Studying cell components in 3D can help to determine the cause of various diseases, among other things. The researchers have published their findings in Nature Communications.
Decoding movement intentions in the brain using ultrasound waves
While many techniques can image brain activity, this was the first time that a new technology, called functional ultrasound imaging, was used to detect motor planning deep within the brain. The team is now applying functional ultrasound decoding to more complicated motor control tasks. At ImPhys, Dr. Maresca is developing ultrasound technologies to image brain activity down to the cellular scale.