Zebrafish swim into a new light, high-throughput, high-resolution, in-vivo imaging of zebrafish

Themes: Life Science & Health, High Tech

Basic research

A TRL is a measure to indicate the matureness of a developing technology. When an innovative idea is discovered it is often not directly suitable for application. Usually such novel idea is subjected to further experimentation, testing and prototyping before it can be implemented. The image below shows how to read TRL’s to categorise the innovative ideas.

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Prevention, diagnosis and treatment of disease is largely based on small animal models, such as the zebrafish. Hence, there is a need for high-throughput, high-resolution, in-vivo imaging of zebrafish.


The researchers are building a new type of optical microscope with which high-resolution, three-dimensional images can be made of the structure and function of the zebrafish.


The first novel microscope is currently build and needs some subsequent improvements. Imaging of zebrafish starts in two to three years and clinical impact is expected subsequently.

Dr. Jeroen Kalkman


A. K. Trull MSc

J. van der Horst MSc