Peggy Bohländer

Biography

Biography

Peggy was born in 1979 in Bautzen, Germany. After completing her apprenticeship as chemical laboratory worker in 1998, she worked until 2006 in a pharmaceutical company. She was responsible for organic synthesis as well as analytical method development. In 2004, she finished a part-time coursework and became a chemical laboratory technician. In order to study chemistry, she left the industry in 2006. In 2011, she obtained her diploma in organic chemistry at the KIT (supervisor Prof. H.-A. Wagenknecht). Afterwards she completed her Ph.D. in Chemistry (summa cum laude) in the same group, studying novel photostable cyanine dyes, DNA modification and the spectroscopic properties of the conjugates. Then she followed postdoctoral research in the area of bonding/debonding on demand at high temperatures in the macromolecular group of Prof. C. Barner-Kowollik. In 2018, she became postdoc at the TU Delft under supervision of Prof. Rienk Eelkema. Currently, her research interests are on peptide and protein modification and mass spectrometry.

Career & Education

2018 – present                              Postdoc, Delft University of Technology

2016 – 2017                                  Postdoc, Karlsruhe Institute of Technology (KIT)

2011 – 2015                                  Ph.D. in Chemistry (summa cum laude), KIT

2006 – 2011                                  Diploma in Chemistry, KIT

2000 – 2004                                 Chemical laboratory technician, part-time coursework

1995 – 2006                                 Chemical laboratory worker, Dr. Willmar Schwabe Pharmaceuticals

Research interests

Protein and peptide modification, Mass Spectroscopy (MALDI and ESI), organic synthesis, fluorescent dyes, nucleic acid chemistry, organic chemistry, biochemistry

Awards & Publications

Awards

2016          MINT Excellence Promotionspreis, Award for the Ph.D. thesis

2015          Wolff & Sohn-Preis, Award for the Ph.D. thesis

2014          Awarded fellowship of KHYS (Karlsruhe House of Young Scientists) for a Research stay at the Chulalongkorn University in Bangkok, Host Prof. T. Vilaivan

Publications

1.    Restrepo-Perez, L.; Huang, G.; Bohlander, P. R.; Worp, N.; Eelkema, R.; Maglia, G.; Joo, C.; Dekker, C.
“Resolving Chemical Modifications to a Single Amino Acid within a Peptide Using a Biological Nanopore”, ACS Nano 2019, 13, (12), 13668-13676.
2.    Zaquen, N.; Haven, J. J.; Rubens, M.; Altintas, O.; Bohlander, P.; Offenloch, J. T.; Barner-Kowollik, C.; Junkers, T. 
“Exploring the Photochemical Reactivity of Multifunctional Photocaged Dienes in Continuous Flow”, Chemphotochem 2019, 3, (11), 1146-1152.
3.    P. R. Bohländer, M. L. Abba, F. Bestvater, H. Allgayer, H. A. Wagenknecht
„Two wavelength-shifting molecular beacons for simultaneous and selective imaging of vesicular miRNA-21 and miRNA-31 in living cancer cells”, Org. Biomol. Chem. 2016, 14, 5001-5006.
4.    C. Schwechheimer, M. Merkel, P. R. Bohländer, H. A. Wagenknecht
“Synthetic Wavelength-Shifting Fluorescent Probes of Nucleic Acids”, In Modified Nucleic Acids, Eds. K. Nakatani, Y. Tor, Springer International Publishing: Cham, 2016, p 83-100.
5.    P. R. Bohländer, T. Vilaivan, H. A. Wagenknecht
„Strand Displacement and Duplex Invasion into Double-Stranded DNA by Pyrrolidinyl Peptide Nucleic Acids”, Org. Biomol. Chem. 2015, 13, 9223-9230.
6.    P. R. Bohländer, H. A. Wagenknecht
“Bright and photostable cyanine‐styryl chromophores with green and red fluorescence color for DNA staining”, MAF 2015, 3, 044003.
7.    H.-K. Walter, P. R. Bohländer, H. A. Wagenknecht
„Development of a Wavelength-Shifting Fluorescent Module for the Adenosine Aptamer Using Photostable Cyanine Dyes”, ChemistryOpen 2015, 4, 92-96.
8.    P. R. Bohländer, H. A. Wagenknecht 
„Synthesis of a Photostable Energy‐Transfer Pair for “DNA Traffic Lights”, 
Eur. J. Org. Chem. 2014, 34, 7547-7551.
9.    P. R. Bohländer, H. A. Wagenknecht
„Synthesis and evaluation of cyanine–styryl dyes with enhanced photostability for fluorescent DNA staining”, Org. Biomol. Chem. 2013, 11, 7458-7462.
10.    M. Rubner, C. Holzhauser, P. R. Bohländer, H. A. Wagenknecht
„A “clickable” styryl dye for fluorescent DNA labeling by excitonic and energy transfer interactions”, Chemistry-A European Journal 2012, 18, 1299-1302.