Five 20k grants for cross-campus bioengineering research projects

News - 15 December 2020 - Communication

In response to the first call for bioengineering research proposals, Delft Bioengineering Institute received a stunning amount of thirteen interfacultary proposals. After a thorough peer review process, eight very good to excellent proposals surfaced. From these, MT BEI has selected the five winning projects listed below. We want to thank all BEI PIs for submitting proposals and all reviewers for their efforts, knowing they were all quite busy already. We hope that 2021 will see the start of a second five-year term for the institute, so we can continue to support these promising cross-campus collaborations!

>> Biochars for reducing methane emissions

Methane has a high global warming potential, and landfill is one of the largest contributors of global human-caused methane emissions. Methane treatment using engineered microbial oxidation systems is one of the ways to reduce these emissions. Biochars, carbon-rich materials produced from sources such as municipal solid wastes, wastewater sludge and wood, have gained interest in the waste management industry as media to enhance control of landfill gas emissions. In this project, led by Julia Gebert of Geoscience & Engineering (CiTG), BEI PIs of four TU Delft faculties team up to investigate the potential of biochars for enhancing microbial methane oxidation in biofilters.

Project title: Effects of biochar on the performance of microbial CH4 oxidation in biofilters to reduce landfill gas emissions.
BEI PIs: Julia Gebert (CiTG/GSE), Wiebren de Jong (3mE/P&E), Aljoscha Wahl (TNW/BT), Martin Pabst (TNW/BT), Thomas Abeel (EWI/Bioinformatics)

>> Regenerating neuronal circuits using ultrasound

People suffering from neurodegenerative disorders such as Alzheimer’s, Parkinson’s Disease and Multiple Sclerosis, have impaired neuronal circuits. Generation of new neuronal circuits by using a patient’s own stem cells may prove helpful in treating the disease. One of the difficulties in inducing neurons from stem cells, is the low efficiency rate we are able to achieve so far. In this project, BEI PIs Tiago Costa of Microelectronics (EWI) and Dimphna Meijer of Bionanoscience (TNW) join forces to explore the use of ultrasound for effectively building active neuronal networks from stem cells.

Project title: SoundCircuit: Regeneration of neuronal circuits using ultrasound
BEI PIs: Tiago Costa (EWI/ME), Dimphna Meijer (TNW/BN)

>> Medical implants to investigate cell mechanobiology

In order to study the cell’s behaviour and differentiation, we need to be able to measure the mechanical, electrical and biochemical signals that are dynamically transmitted throughout the cells. This requires the creation of biomaterial models equipped with different sensor types. In this project, BEI PIs Mohammad J. Mirzaali of Biomechanical Engineering (3mE) and Massimo Mastrangeli of Microelectronics (EWI) will team up to design, fabricate and test the proof-of-concept for medical implants equipped with force sensors that can reach a sensitivity level of one micronewton, so the mechanobiology of cells can be effectively investigated.

Project title: Sixth Sense Biomaterials
BEI PIs: Mohammad J. Mirzaali (3mE/BM), Massimo Mastrangeli (EWI/ME)

>> Advanced cellular nanoimaging

Structural biology has been essential in understanding the cell. Studying the dynamics of biological systems requires advanced imaging tools, particularly those that can bring both high spatial and temporal resolutions. In this project, BEI PIs Chirlmin Joo of Bionanoscience (TNW) and Carlas Smith of Delft Centre for Systems and Control (3mE) will join forces to develop a novel methodology for fast absolute FRET distance measurement, taking advantage of smFRET (fast but biased molecular dynamics) and localization microscopy (unbiased but static localization).

Project title: New structural biology by integrating nanoscopy and single-molecule Forster resonance energy transfer
BEI PIs: Chirlmin Joo (TNW/BN), Carlas Smith (3mE/DCSC)

>> 3D-printing bacterial electrodes for CO2 conversion

In order to achieve a sustainable future, we need to use abundant molecules such as CO2, water and renewable electricity to create our organic chemicals and fuels. Microorganisms have the ability to enable upgrading of CO2 by microbial electrosynthesis. In this project, Ludovic Jourdin of Biotechnology (TNW) and Kunal Masania of the Shaping Matter Lab (LR) will team up to explore strategies to shape carbon electrodes into hierarchical porous electrodes for microbial electrosynthesis and study the role of hierarchical porosity on microbial and electrochemical activity.

Project title: BACTRODE: Hierarchical 3D-printing of bacterial electrodes for breakthrough in CO2 conversion
BEI PIs: Ludovic Jourdin (TNW/BT), Kunal Masania (LR/SML)