Our research concerns the development of high-resolution microscopy systems and optical fabrication systems. The research transcends the boundaries between physics, biology and engineering to visualize cellular processes in a wide range of biological samples. It breaks away from the traditional design philosophy of mere addition of optimal components into a system, to instead apply optimal information processing for all components present in the system. The methodology uses adaptive elements to maximize the recorded information content of the optical system, which we utilize to reconstruct an image with super-resolution. This has led to advances in biomedical imaging, including in confocal, multiphoton and wide-field microscopy.

Our experience on optical and photonic systems covers a broad range of applications on the interface between advanced signal processing and extreme sensitive and high resolution sensors. This includes the development of a method that obtains the best possible estimate of the position of single molecules, the development of the first adaptive optical super-resolution microscope with single molecule sensitivity, and a framework to perform optimal detection of single molecules in low signal to background imaging conditions.

Carlas Smith

Section Leader