Dr. Kristin Grußmayer

Research Theme(s): Single-molecule Biophysics, Cell Biology

Research Interests: Multiplane Microscopy, Super-resolution Imaging (SMLM, SOFI & SIM), Quantitative Phase Imaging, Fluorescence Labeling, Neurodegenerative Disease


Kristin Grußmayer is an assistant professor at the Department of Bionanoscience, TU Delft and the Kavli Institute of Nanoscience Delft. She studied Physics at Heidelberg University with a specialization in Biophysics. As the Heidelberg-Cornell fellow and with support from the Fulbright program, she spent a year at Cornell University. She carried out her Diploma and doctoral thesis work in the Institute for Physical Chemistry & CellNetworks Cluster of Excellence at the BioQuant Center in Heidelberg; during her doctoral studies she was as a fellow of the DFG graduate college GRK 1114. She worked on transcription factor DNA biosensors and established a method for counting molecules based on photon statistics for quantification in biological systems and material science. After her PhD in Physics (summa cum laude ), she moved to Switzerland for a postdoc at the École Polytechnique Fédérale de Lausanne (EPFL). As a Horizon 2020 Marie Sklodowska-Curie fellow, she became an expert in multiplane super-resolution and quantitative phase imaging and collaborated with neurobiologists. Since 2021, she leads an independent research group at TU Delft. Her lab develops microscopy and analysis tools, establishes new classes of fluorescence probes, and applies them to address relevant questions in molecular and cell biology.


For further information regarding current research and available projects, visit Grußmayer Lab.


Kristin Grußmayer will be teaching in the Nanobiology program.

Highlight Publications

1. K. S. Grußmayer, T. Lukes, T. Lasser, A. Radenovic, Self-blinking Dyes unlock High-order and Multi-plane Super-resolution Optical Fluctuation Imaging, ACS Nano June 2020, 14, 7, 9156–9165.

2. A. Descloux, K. S. Grußmayer, and A. Radenovic, Parameter-free image resolution estimation based on decorrelation analysis, Nature Methods Aug. 2019, 16, 918–924. 

3. A. Descloux, K. S. Grußmayer (equal contribution), E. Bostan, T. Lukes, A. Bouwens, A. Sharipov, S. Geissbuehler, A.-L. Mahul-Mellier, H. A. Lashuel, M. Leutenegger, and T. Lasser, Combined multi-plane phase retrieval and super-resolution optical fluctuation imaging for 4D cell microscopy, Nature Photonics Feb. 2018, 12, 165–172 

4.K. S. Grußmayer and D.–P. Herten, Time-resolved molecule counting by photon statistics across the visible spectrum, PhysChemChemPhys Mar. 2017, 19, 8962–8969.


Assistant Professor

Kristin Grußmayer

Management Assistant

Nadine Kuijvenhoven