News

New Cas9 model maps DNA cutting behaviour for the first time

Researchers from the TU Delft have come up with a physical-based model that establishes a quantitative framework on how gene-editing with CRISPR-Cas9 works, and allows them to predict where, with what probability, and why targeting errors (off-targets) occur. This research, which has been published in Nature Communications, gives us a first detailed physical understanding of the mechanism behind the most important gene editing platform of today.

Cell unstuck: how a glue-like protein can make our cells move

An essential aspect of the cells in our body is their ability to move, to repair certain tissues or chase intruders, for example: but how do they do it? Scientists from TU Delft, AMOLF and Utrecht University reveal how glue-like proteins called crosslinkers could not only help to hold the whole cell together passively, but surprisingly cause the cell to move as well. The research is now published in PNAS.

ERC Proof of Concept Grant for Arjen Jakobi

Arjen Jakobi (Department of Bionanoscience) receives the ERC Proof of Concept Grant for his groundbreaking research on cryogenic electron microscopy (cryo-EM). "This grant will allow us to take our new CryoChip technique for high resolution images of protein molecules to the next level for the development of new drugs," says Jakobi.

Effectiveness of 2G and 3G has declined

At the request of the Dutch Ministry of Health, Welfare and Sport, researchers from TU Delft, UMC Utrecht and Populytics investigated the extent to which the various types of COVID certificates (coronatoegangsbewijs, CTB) can help to prevent the spread of COVID-19 in society. The 3G (vaccinated, recovered, tested) and 2G (vaccinated, recovered) rules are currently a lot less effective in curbing the spread of the virus than they were two months ago. A 1G policy (only people who have recently tested negative are given access) is much more effective. But, even if a 1G policy were to be introduced today, the reproduction number would not drop below 1.0.

Super-fast technique measures heme enzyme reaction as it happens

Researchers from TU Delft found an unexpected new enzyme intermediate at work in enzymes that contain heme, a cofactor that’s vital for many processes in our body such as the breaking down of toxins in the liver. The researchers used new, rapid techniques, which are less invasive than existing methods. The results, published in ACS Catalysis, increase our understanding of heme proteins and enzymes and how they can be engineered.
Richard Goossens on the podcast episode #24 cover

Out of the Blue #24: Clashing Disciplines in Healthcare - Richard Goossens

A design researcher and a doctor sit together for a coffee in a hospital café. They discuss and draw on a napkin what a joined education programme for designers and medical students could look like. What if doctors understood design for healthcare, and designers the healthcare world?
Maaike Kleinsmann podcast episode cover

Out of the Blue #23: A Designer walks into a Hospital - Maaike Kleinsmann

How can design research improve our health, and is it better to design for prevention or for the cure? We kick off our triptych on Design & Health with Delft Design Professor Maaike Kleinsmann. Ianus and co-host Marc talk with her about working with healthcare professionals as a design researcher, what all this new remote-sensing health-tech for consumers means for personal health challenges and the issue of health data and privacy. And dealing with Strava-men in tight lycra suits.

New method predicts drug response of cancer patients

Researchers from Delft University of Technology and the Netherlands Cancer Institute (NKI) have developed an algorithm to predict patient response to anti-cancer drugs. This allows us to identify more rapidly if some drugs can have a positive effect on a specific patient, even for complicated medicines such as chemotherapies where response is typically hard to predict. This method is called TRANSACT and makes use of the wealth of data previously collected through research with cell lines.

Fitrim: Wheelchair power to the people

Just imagine that you just drove your wheelchair for half an hour over bumpy roads and some grassy spots, only to have your fitbit or smartphone activity tracker inform you that you took only 50 steps, burned virtually no calories and that you shouldn’t be such a couch potato. ‘There has to be a better way,’ Marit van Dijk thought. A seed grant from Delft Health Initiative and the TU Delft Sports Engineering Institute makes the difference.

Self-experimentation for long-lasting physical activity promotion in cardiac rehabilitation

A heart-attack may very well be the ultimate wake-up call when it comes to changing your lifestyle and behaviour. Even so, four years on most cardiac patients have relapsed to a very low fitness and physical activity level. Explorative self-experimentation, developed by Jos Kraal and colleagues, makes changing physical activity behaviour for cardiac patients more personal.

The formation of kidney stones on a microscale

Researchers from TU Delft developed a method to watch the formation of kidney stones on a microscale, in a so called microfluidic platform. By slightly adjusting the pH and the concentration of specific minerals, the formation could be slowed down or inhibited completely. The research is now published in Biomicrofluidics.

Healthy Start: Increasing opportunities for young people

Scanning a single protein, one amino acid at a time

Using nanopore DNA sequencing technology, researchers from TU Delft and the University of Illinois have managed to scan a single protein: by slowly moving a linearized protein through a tiny nanopore, one amino acid at the time, the researchers were able to read off electric currents that relate to the information content of the protein. The researchers published their proof-of-concept in Science today. The new single-molecule peptide reader marks a breakthrough in protein identification, and opens the way towards single-molecule protein sequencing and cataloguing the proteins inside a single cell.

Mechanism underlying the emergence of virus variants unravelled

An international consortium, led by Delft University of Technology and the University of North Carolina, has for the first time succeeded in probing the molecular origins of recombination in RNA viruses. Hiccups during the copying process of viruses cause recombination to take place: the exchange of segments of viral RNA.

Design for Deaf culture and health

Patients failing to take their medication in the prescribed manner is a widespread problem across society. But a combination of social barriers, discrimination and difficulty with written language mean that the Deaf community has a greater struggle. This medication non-adherence can be dangerous for patients, prolong sickness and strained healthcare systems. Ph.D. researcher Prangnat Chininthorn wanted to find ways to improve this and help Deaf people better manage their own health.

Mapping the brain motor cortex region in detail

In a major study funded by U.S Government, an international consortium of researchers successfully mapped the different types of brain cells in the motor cortex. Scientists from the Leiden University Medical Center (LUMC) and Delft University of Technology (TU Delft) contributed specific expertise to visualize the data.

Researchers unravel molecular replication process of covid-19

Is there a way to stop SARS-CoV-2-? An international consortium, led by biophysicist David Dulin at VU Amsterdam and in collaboration with Martin Depken from TU Delft, has investigated how to interfere with the viral genome-replication process at the molecular level.

Understanding human-robot interaction critical in design of rehabilitation systems

Robotic body-weight support (BWS) devices can play a key role in helping people with neurological disorders to improve their walking. The team that developed the advanced body-weight support device RYSEN in 2018 has since gained more fundamental insight in BWS but also concludes that improvement in this field is necessary.

Stronger is not always better

Rather than one key and one strong lock, biology often uses tens or hundreds of weaker links to bind parts together, such as cells membranes. This allows for selectivity and also reversibility: the binding can also be undone. Researcher Christine Linne and colleagues from Leiden University, TU Delft and Imperial College London first caught this phenomenon using spheres or colloids, and published September 1st in the journal PNAS.

Catch me if you can: a revolutionary method to study single proteins

Researchers from the technical universities of Delft and Munich have invented a new type of molecular trap that can hold a single protein in place for hours to study its natural behavior – a million times longer than before.

New CRISPR-Cas system cuts virus RNA

Researchers from the group of Stan Brouns (Delft University of Technology) have discovered a new CRISPR-Cas system that cuts RNA. The study will be published on August 26 in Science and is expected to offer many opportunities for the development of new applications in genetic research and biotechnology.

The Spaceman has a job for you

A cancer diagnosis is an awful and upsetting event for anyone. For the parents of young children, it is nearly unthinkable. Yet, every year, for some 35,000 families around Europe, it is a reality. PhD researcher Patrizia D'Olivo wanted to help them with her research.

Getting personal with dementia care

Caring for people with dementia is not a one-size-fits-all kind of thing. That’s because people have different personalities, life experiences and preferences. Taking these things into account, Gubing Wang’s PhD explored how to facilitate designers and healthcare professionals with designing for personalised dementia care.

A new spin on making minimal cells

The ability of a cell to separate its own matter from its surroundings is a basic requirement for life. A team of researchers at AMOLF and Delft University of Technology have managed to create a synthetic container, or lipid vesicle, that is able to hold a range of different biological systems: from a cytoskeleton to entire E.coli bacteria. Their findings on this optimized cDICE method, which has the potential to reveal the inner workings of life, are published in ACS Synthetic Biology on DATE.

Researchers make 3D image with light microscope

For the first time, Delft researchers have succeeded in making a three-dimensional image of a cellular component using light. The component in question is the nuclear pore complex: tunnels that facilitate traffic to and from the cell nucleus. Studying cell components in 3D can help to determine the cause of various diseases, among other things. The researchers have published their findings in Nature Communications.