Z. (Ze) Yu

Z. (Ze) Yu

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Delivering beneficial macromolecules across the cellular membrane is a significant challenge since these molecules are too large to shuttle into cells through the nanochannels. Construction of synthetic nanopores for the transport of large biological cargoes would be a step forward. De novo design using DNA nanotechnology gives high structural precision and programmability, dynamic nano-mechanical control and extensive chemical modifications. In this project I will develop the first mechanically-adaptable nanopores for size-selective biomolecule transport across cell membrane by uniquely combining DNA origami nanotechnology, machine-inspired design and synthetic biology. 

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