Octoscope: a compact microscope for voltage imaging
Voltage imaging and optogenetics offer new routes to optically detect and influence neural dynamics. Optimized hardware is necessary to make the most of these new techniques. In this study the Octoscope, a versatile, multimodal device for all-optical electrophysiology is presented. The researchers illustrate its concept and design and demonstrate its capability to perform both 1-photon and 2-photon voltage imaging with spatial and temporal light patterning, in both inverted and upright configurations, in vitro and in vivo.
A compact microscope for voltage imaging
Xin Meng, Lex Huismans, Teun Huijben, Greta Szabo, Ruud van Tol, Izak de Heer, Srividya Ganapathy and Daan Brinks
Journal of Optics, Volume 24, Number 5