26 April 2018
Cas3: a biological fishing rod and a shredder rolled into one
CRISPR-Cas9 has made gene editing a lot easier and will eventually help us erase hereditary diseases from our DNA.
20 April 2018
Researchers build DNA replication in a model synthetic cell
Researchers at Delft University of Technology, in collaboration with colleagues at the Autonomous University of Madrid, have created an artificial DNA blueprint for the replication of DNA in a cell-like structure.
22 February 2018
Loops, loops, and more loops: This is how your DNA gets organised
Researchers from the Kavli Institute of Delft University and EMBL Heidelberg now managed for the first time to isolate and film and witnessed—in real time—how a single protein complex called condensin reels in DNA to extrude a loop.
07 February 2018
Mathematics explains why Crispr-Cas9 sometimes cuts the wrong DNA
The discovery of the Cas9 protein has been of great value to medical science. It has simplified gene editing tremendously, and may even make it possible to eliminate many hereditary diseases in the near future. Using Cas9, researchers have the ability to cut DNA in a cell to correct mutated genes, or paste new pieces of genetic material into the newly opened spot. Initially, the Crispr-Cas9 system seemed to be extremely accurate. But unfortunately, it is now apparent that Cas9 sometimes also cuts other DNA sequences similar to the exact sequences it was programmed to target. Scientists at Delft University of Technology have developed a mathematical model that explains why Cas9 cuts some DNA sequences while leaving others alone.
01 February 2018
Clive Brown of Oxford Nanopore at Bioengineering Institute kickoff
On Tuesday 27 March, TU Delft will launch the Delft Bioengineering Institute. Main speaker is Clive Brown, Chief Technology Officer at DNA sequencing specialist Oxford Nanopore Technologies.
07 December 2017
Three postdocs for Applied Sciences in ‘LEaDing Fellows’ programme
Thanks to the European Unions ‘LEaDing Fellows Postdocs Programme’, the Faculty of Applied Sciences has the honour to welcome three new postdocs: Aurora Dols Perez from Spain, Dowon Bae from South Korea and Andrea Gutierrez from Colombia.
14 November 2017
Student team from TU Delft wins international Synthetic Biology competition
Students from TU Delft have won the International Genetically Engineered Machine (iGEM) competition in Boston. Earlier this week, the team presented their idea for a quick, on-site method to demonstrate antibiotic resistance in bacteria in dairy cattle. The test would allow a farmer to adjust the treatment if resistant bacteria is detected, and reduce the unnecessary usage of antibiotics.
26 October 2017
Identifying the mechanism for a new class of antiviral drugs could hasten their approval
New research shows that a new class of antiviral drugs works by causing the virus' replication machinery to pause and backtrack, preventing the virus from efficiently replicating.
11 September 2017
Cees Dekker receives 2017 Nanosmat Prize
On 11 September, prof. dr. Cees Dekker visited Paris to receive the Nanosmat Prize 2017.
07 September 2017
Discovery of chromosome motor supports DNA loop extrusion
It is one of the great mysteries in biology: how does a cell neatly distribute its replicated DNA between two daughter cells?