Robin de Kruijff

Robin de Kruijff currently works as Assistant Professor at Delft University of Technology, where her research focuses on the compartmentology of elements and radionuclides in medicine, specifically looking into the production, distribution kinetics and sample analysis. As such, she aims to (1) obtain a better understanding of human and animal metabolism, (2) evaluate the uptake, distribution, intercompartmental kinetics and excretion of metals, and (3) develop (radio)isotopes for disease diagnosis or treatment. Prior to starting her appointment at Delft University of Technology, she was a Postdoc at Argonne National Laboratory where she focused mainly on radionuclide production and separation. She holds a B.S. in Applied Physics from Delft University of Technology, the Netherlands, and she obtained her Applied Physics M.S. with a specialization in Nuclear Science and Engineering, after which she started her PhD at the same university. During her PhD thesis, she investigated the use of polymeric nanocarriers to retain recoiling alpha-emitting daughters of 225Ac. She spent part of her time working at the university hospital Radboudumc, the Netherlands, on preclinical studies. She currently serves as Chair of the Dutch Young Generation, a network for young employees working in the nuclear field.

Biography
  • 2019-present: Assistant Professor, Delft University of Technology, Delft, the Netherlands
    Research focusing on the compartmentology of elements and radionuclides in medicine, investigating novel radionuclides for medical purposes as well as evaluating the metabolism of different compounds like dietary supplements.
  • 2018-2019: Postdoc, Argonne National Laboratory, IL, United States
    Developed novel radioisotope production pathways using photonuclear and ion-induced activation, including 67Cu, 47Sc, and 211Rn/211At, and their subsequent processing, purification as well as recycling of the target material. Performed photonuclear data cross section measurements and developed synthesis pathways for radio-assisted chemotherapy.
  • 2018: Postdoc, Delft University of Technology, Delft, the Netherlands
    Investigated the in vivo characteristics of polymeric nanocarriers.
  • 2016-2018: Visiting researcher, Radboudumc, Nijmegen, the Netherlands
    Determining circulation and therapeutic efficacy of 225Ac containing polymersomes in mouse models.
  • 2014-2018: PhD candidate, Delft University of Technology, Delft, the Netherlands
    Worked on the radiolabeling, in vitro and in vivo evaluation of polymersomes as carrier for the 225Ac therapeutic radionuclide.
  • 2012-2013: Research intern, CENA/USP, Piracicaba, Brazil
    Assessed the representativeness of soil content estimation probing methods for sugarcane trucks using either instrumental neutron activation analysis (INAA) or the ash method.
Select Publications
  • R.M. de Kruijff, R. Raavé, A. Kip, J. Molkenboer-Kuenen, S.J. Roobol, J. Essers, S. Heskamp, A.G. Denkova, Elucidating the Influence of Tumor Presence on the Polymersome Circulation Time in Mice, Pharmaceutics, 2019 20;11(5)
  • R.M. de Kruijff, A.J.G.M. van der Meer, C.A.A. Windmeijer, J.J.M. Kouwenberg, A. Morgenstern, F. Bruchertseifer, P. Sminia, A.G. Denkova, The therapeutic potential of polymersomes loaded with 225Ac evaluated in 2D and 3D in vitro glioma models. Eur. J. Pharm. Biopharm. 2018, 127.
  • R.M. de Kruijff, A. Arranja, A.G. Denkova, Radiolabeling methods and nuclear imaging techniques in the design of new polymeric carriers for cancer therapy. Curr. Appl. Polymer Science. 2018, 2, 1-15
  • R.M. de Kruijff, K. Drost, L. Thijssen, A. Morgenstern, F. Bruchertseifer, D. Lathouwers, H.T. Wolterbeek, A.G. Denkova, Improved 225Ac Daughter Retention in InPO4 Containing Polymersomes. Appl. Radiat. Isot. 2017, 128, 183–189.       
  • R.M. de Kruijff, H.T. Wolterbeek, A.G. Denkova, A critical review of alpha radionuclide therapy-how to deal with recoiling daughters? Pharmaceuticals 2015, 8.
Synergistic Activities
  • President of the Dutch Young Generation, an organization for employees working at nuclear institutes throughout the Netherlands. For more info: https://www.dutchyounggeneration.nl

Dr.ir. Robin de Kruijff

Assistant Professor