The department of Imaging Physics develops novel instrumentation and imaging technologies. We are driven by our scientific curiosity and problem oriented nature in research with a strong connection to industry and to educate future leaders in the field of imaging science.
The scientific staff of the department is formed by independent Principal Investigators or Educators.
3-in-1 microscope shows researchers the way to proteinsPhysicists from TU Delft have developed a 3-in-1 microscope where a light beam, electron beam and ion beam work together to precisely cut out specific slices from biological samples. These slices are indispensable for biomolecular research into new generations of medicines. The invention was published in the journal eLife on 1 December.
Face2Phase 3rd edition realized on November 7-9, 2022 in DelftThe conference addressed phase information in imaging with topics such as lensless imaging, phase retrieval, adaptive and active optics, ptychography, holography, tomography. We also had the honour to have 14 invited speakers from all over the world and many oral and poster presentations. The conference attracted about 100 participants from the Netherlands and from abroad.
Selina Teurlings joined ImPhys as Biolab TechnicianSelina Teurlings joined ImPhys as Biolab Technician. She has a bachelor in Applied Biology and a master in Animal Sciences. Selina has worked for 2 years at the Van Woerden lab (Erasmus MC) on the role of CAMK2A in ischemia as well as the role of CAMK2 in neurodevelopment and neurodevelopmental disorders.
SPIE student chapter organized a school of physicsFrom 9 to 11 November the SPIE student chapter of Delft organized a 2.5-day school of physics at the university. Several (international) speakers were invited to give lectures to PhD students and others on topics ranging from mathematical physics to imaging without lenses.
Myron Hensgens joined ImPhys as a PhD studentMyron completed his master’s in Life Science & Technology at the University of Leiden. Since October 1st he joined the MInT group at ImPhys as a PhD student. His research will focus on localizing proteins within the nucleus of the cell with help of DNA-PAINT supervised by at the group of Hylkje Geertsema
Martijn Adriaans joined ImPhys as PhD studentMartijn has completed his master’s in Applied Physics at TU-Eindhoven with a thesis focused on multipole correction for a multi-beam SEM source which was done in collaboration with the Thermo-Fisher company in Eindhoven. His project focus is to develop a MEMS Monochromtor for electron microcopy applications supervised by Ali Mohammadi-Gheidari.
In the spotlight
In the spotlight
Spying on microscopic blood vessels in the heart and brain
Sebastian Weingärtner will use Magnetic Resonance Imaging (MRI) to exploit hydrogen atoms as microscopic spies to investigate the smallest blood vessels in the body. These ultra-small blood vessels are so fine that they evaded medical imaging so far, yet a better understanding of their features could be a transformative step towards better treatment of diseases like heart failure and dementia.
From light spots to supersharp images
Making detailed 3D images of proteins in living cells with a special light microscope, without damaging those cells. That is what Sjoerd Stallinga, winner of an ERC Advanced grant worth 2.3 million euros, wants to achieve. In order to do so he is going to scan samples nanometer by nanometer using a sophisticated 3D light pattern in an approach that requires extensive collaboration between different disciplines.
Spotlight on aggressive cancer cells
Metastases in cancer are often caused by a few abnormal cells. These behave more aggressively than the other cancer cells in a tumour. Miao-Ping Chien and Daan Brinks are working together, from two different universities, on a method to detect these cells. Their research has now been published in Nature Biomedical Engineering
How to find structurally different molecules before they disappear in the average?
Particle fusion for single molecule localization microscopy improves signal-to-noise ratio and overcomes underlabeling, but ignores structural heterogeneity or conformational variability. This study presents a-priori knowledge-free unsupervised classification of structurally different particles employing the Bhattacharya cost function as dissimilarity metric.
The impact of noise on Structured Illumination Microscopy image reconstructions
Super-resolution structured illumination microscopy (SIM) has become a widely used method for biological imaging. Standard reconstruction algorithms, however, are prone to generate noise-specific artifacts that limit their applicability for lower signal-to-noise data. Here we present a physically realistic noise model that explains the structured noise artifact, which we then use to motivate new complementary reconstruction approaches.
A new tool to understand the brain
How does our brain work? An international team of researchers, including lead author Daan Brinks of TU Delft, has taken another step towards answering that question. They have created a new tool that allows them to image electrical signals in brains with an unprecedented combination of precision, resolution, sensitivity, and depth.
Researchers make 3D image with light microscope
For the first time, Delft researchers have succeeded in making a three-dimensional image of a cellular component using light. The component in question is the nuclear pore complex: tunnels that facilitate traffic to and from the cell nucleus. Studying cell components in 3D can help to determine the cause of various diseases, among other things. The researchers have published their findings in Nature Communications.
Decoding movement intentions in the brain using ultrasound waves
While many techniques can image brain activity, this was the first time that a new technology, called functional ultrasound imaging, was used to detect motor planning deep within the brain. The team is now applying functional ultrasound decoding to more complicated motor control tasks. At ImPhys, Dr. Maresca is developing ultrasound technologies to image brain activity down to the cellular scale.