The department of Imaging Physics develops novel instrumentation and imaging technologies. We are driven by our scientific curiosity and problem oriented nature in research with a strong connection to industry and to educate future leaders in the field of imaging science.
The scientific staff of the department is formed by independent Principle Investigators or Educators.
06 December 2017
Publication Niels Noordzij, Kees Hagen and team in Science Advances
Inspired by the Japanese art of paper folding (origami), researchers at TU Delft are developing an alternative to 3D printing that allows the final products to have many more functionalities than what is possible with 3D printing. Those additional functionalities could, for instance, be used in medical implants or devices incorporating flexible electronics. In their publication in Science Advances on Wednesday November 29th, the scientists have successfully applied their technique to lattice structures.
23 November 2017
NIH has extended running grant Bernd Rieger by two years
The American Institute of Health (NIH) has extended a running grant by two years in the amount of 660.000 dollars for a collaboration between Dr. Bernd Rieger of the Department of Imaging Physics and the University of Massachusetts at Worcester to create "4D Nucleome Imaging Tools”.
16 February 2017
Work in progress: Realisation of the VLLAIR Lab
The building activities for our new VLLAIR lab (D1-Wing ground floor) are more or less completed. Gradually the equipment and furniture are moved in. Please find below a “sneak preview” of the lab.
13 February 2017
Joost de Jong started his MSc project
Joost will work together with Robert Moerland on Polarization STED at cryogenic temperatures
From light spots to supersharp images
Making detailed 3D images of proteins in living cells with a special light microscope, without damaging those cells. That is what Sjoerd Stallinga, winner of an ERC Advanced grant worth 2.3 million euros, wants to achieve. In order to do so he is going to scan samples nanometer by nanometer using a sophisticated 3D light pattern in an approach that requires extensive collaboration between different disciplines.
Spotlight on aggressive cancer cells
Metastases in cancer are often caused by a few abnormal cells. These behave more aggressively than the other cancer cells in a tumour. Miao-Ping Chien and Daan Brinks are working together, from two different universities, on a method to detect these cells. Their research has now been published in Nature Biomedical Engineering
How to find structurally different molecules before they disappear in the average?
Particle fusion for single molecule localization microscopy improves signal-to-noise ratio and overcomes underlabeling, but ignores structural heterogeneity or conformational variability. This study presents a-priori knowledge-free unsupervised classification of structurally different particles employing the Bhattacharya cost function as dissimilarity metric.
The impact of noise on Structured Illumination Microscopy image reconstructions
Super-resolution structured illumination microscopy (SIM) has become a widely used method for biological imaging. Standard reconstruction algorithms, however, are prone to generate noise-specific artifacts that limit their applicability for lower signal-to-noise data. Here we present a physically realistic noise model that explains the structured noise artifact, which we then use to motivate new complementary reconstruction approaches.
A new tool to understand the brain
How does our brain work? An international team of researchers, including lead author Daan Brinks of TU Delft, has taken another step towards answering that question. They have created a new tool that allows them to image electrical signals in brains with an unprecedented combination of precision, resolution, sensitivity, and depth.
Researchers make 3D image with light microscope
For the first time, Delft researchers have succeeded in making a three-dimensional image of a cellular component using light. The component in question is the nuclear pore complex: tunnels that facilitate traffic to and from the cell nucleus. Studying cell components in 3D can help to determine the cause of various diseases, among other things. The researchers have published their findings in Nature Communications.
Decoding movement intentions in the brain using ultrasound waves
While many techniques can image brain activity, this was the first time that a new technology, called functional ultrasound imaging, was used to detect motor planning deep within the brain. The team is now applying functional ultrasound decoding to more complicated motor control tasks. At ImPhys, Dr. Maresca is developing ultrasound technologies to image brain activity down to the cellular scale.