The department of Imaging Physics develops novel instrumentation and imaging technologies. We are driven by our scientific curiosity and problem oriented nature in research with a strong connection to industry and to educate future leaders in the field of imaging science.
The scientific staff of the department is formed by independent Principal Investigators or Educators.
IEEE UFFC-S Special Topic School on Waves and Transducers
Last October, the IEEE-UFFC-S special-topic school on Waves and Transducers took place at Delft University and chaired by Koen W.A. van Dongen from Delft University of Technology. The school was attended by 32 participants from academia and industry who all shared a common interest in ultrasound technology.
GUSTO arrived on AntarcticaNASA’s GUSTO balloon observatory has arrived on Antarctica onboard the Wallops C-130 airplane. It is scheduled for launch around the 15th of December. GUSTO is equipped with three 8-pixel far-infrared cameras delivered by SRON and TU Delft and will carry out the first large-scale survey with velocity-resolved imaging of the spectral lines emitted by three cosmic elements between stars.
The radiologist’s assistantQian Tao was interviewed by TU Delta on using AI in radiology. Qian is co-director of the CHEME AI Lab, one of our 24 TU Delft | AI Labs.
The CHEME Lab investigates knowledge-driven AI and demonstrates its potential within two applied science domains in particular – chemical engineering and imaging physics. Artur Schweidtmann is the lab's other co-director; Lukas Schulze Balhorn, Qinghe Gao, Changchun Yang and Yidong Zhao are PhD students in the CHEME AI lab.
Alexander Heemels wins poster prize at the Dutch Photonics EventAlexander Heemels, PhD student in the ImPhys Optica department, won the poster prize at the Dutch Photonics Event. The poster titled "A novel tool to design freeform optics" presents how algorithmic differentiable ray tracing together with THB-splines can be used to design freeform lenses for illumination applications.
In the spotlight
In the spotlight
Advanced microscopy to understand life and fight disease
In the NL-BI consortium, scientists from all Dutch academic research centres will together develop and integrate state-of-the-art microscopy with technologies and services in different nodes. This will enable access for all scientists to revolutionise fundamental insights into the building blocks of life, enable scientific breakthroughs, and advance applications towards society for overcoming life-threatening disease, including cancer, metabolic, cardiovascular, and neurodegenerative disorders.
Pushing the boundaries of ultrasound
Physicist David Maresca has received a Chan Zuckerberg Initiative Dynamic Imaging grant to develop a next-generation medical ultrasound tool. While state-of-the-art ultrasound imaging, known to most as a baby’s first picture, can show our anatomy and organs, the new tool will be able to zoom in much further, all the way down to the level of the cells in our body. Maresca: “Ultrasound is a safe but also affordable and widespread technology. If we can push the boundaries and make it more sensitive, it will potentially help a lot of people.”
Microscope shows researchers the way to proteins
Physicists from TU Delft, Daan Boltje and Jacob Hoogenboom have developed a 3-in-1 microscope where a light beam, electron beam and ion beam work together to precisely cut out specific slices from biological samples. These slices are indispensable for biomolecular research into new generations of medicines.
Spying on microscopic blood vessels in the heart and brain
Sebastian Weingärtner will use Magnetic Resonance Imaging (MRI) to exploit hydrogen atoms as microscopic spies to investigate the smallest blood vessels in the body. These ultra-small blood vessels are so fine that they evaded medical imaging so far, yet a better understanding of their features could be a transformative step towards better treatment of diseases like heart failure and dementia.
From light spots to supersharp images
Making detailed 3D images of proteins in living cells with a special light microscope, without damaging those cells. That is what Sjoerd Stallinga, winner of an ERC Advanced grant worth 2.3 million euros, wants to achieve. In order to do so he is going to scan samples nanometer by nanometer using a sophisticated 3D light pattern in an approach that requires extensive collaboration between different disciplines.
Spotlight on aggressive cancer cells
Metastases in cancer are often caused by a few abnormal cells. These behave more aggressively than the other cancer cells in a tumour. Miao-Ping Chien and Daan Brinks are working together, from two different universities, on a method to detect these cells. Their research has now been published in Nature Biomedical Engineering
How to find structurally different molecules before they disappear in the average?
Particle fusion for single molecule localization microscopy improves signal-to-noise ratio and overcomes underlabeling, but ignores structural heterogeneity or conformational variability. This study presents a-priori knowledge-free unsupervised classification of structurally different particles employing the Bhattacharya cost function as dissimilarity metric.
The impact of noise on Structured Illumination Microscopy image reconstructions
Super-resolution structured illumination microscopy (SIM) has become a widely used method for biological imaging. Standard reconstruction algorithms, however, are prone to generate noise-specific artifacts that limit their applicability for lower signal-to-noise data. Here we present a physically realistic noise model that explains the structured noise artifact, which we then use to motivate new complementary reconstruction approaches.
A new tool to understand the brain
How does our brain work? An international team of researchers, including lead author Daan Brinks of TU Delft, has taken another step towards answering that question. They have created a new tool that allows them to image electrical signals in brains with an unprecedented combination of precision, resolution, sensitivity, and depth.
Researchers make 3D image with light microscope
For the first time, Delft researchers have succeeded in making a three-dimensional image of a cellular component using light. The component in question is the nuclear pore complex: tunnels that facilitate traffic to and from the cell nucleus. Studying cell components in 3D can help to determine the cause of various diseases, among other things. The researchers have published their findings in Nature Communications.
Decoding movement intentions in the brain using ultrasound waves
While many techniques can image brain activity, this was the first time that a new technology, called functional ultrasound imaging, was used to detect motor planning deep within the brain. The team is now applying functional ultrasound decoding to more complicated motor control tasks. At ImPhys, Dr. Maresca is developing ultrasound technologies to image brain activity down to the cellular scale.