The department of Imaging Physics develops novel instrumentation and imaging technologies. We are driven by our scientific curiosity and problem oriented nature in research with a strong connection to industry and to educate future leaders in the field of imaging science.
The scientific staff of the department is formed by independent Principal Investigators or Educators.
Achere Eyong joined ImPhys as MSc studentAchere Eyong is currently doing his master’s program in Nanobiology jointly at the TU Delft and Erasmus MC. This relatively new program teaches applied physics, programming and modelling to tackle biophysical problems at the nanoscale. His academic interests lies in optical systems and computational solutions to problems related to biophysics.
He will be joining the Menzel lab from the 4th of September.
Simon van Staalduine joined ImPhys as MSc studentSimon van Staalduine will be joining the ImPhys department in September and work in the Menzel Lab on improving the information acquisition side of computational scattered light imaging! This is going to be part of his Master's thesis in Nanobiology.
Loes Ettema joined ImPhys as PhD studentLoes Ettema started her PhD in the lab of Miriam Menzel. She will work on dedicated tissue preparation and measurement protocols for Computational Scattered Light Imaging, in order to facilitate the reconstruction of highly interwoven fiber structures in the brain and other biological tissues.
KIC grant awarded to improve imaging of semiconductor chipsThe Dutch Research Council (NWO) has awarded a grant to research on more efficient production of even smaller computer chips in the KIC call ‘Demand-driven Partnerships for Consortia’. Researchers from Delft University of Technology and ARCNL are collaborating with ASML in order to inspect computer chips more precisely and faster with help of electrons. The Knowledge and Innovation Covenant (KIC) research programme stands for pioneering innovative solutions with social and economic impact. NWO funds the research with almost 2 million euros, ASML contributes with over 2.3 million co-funding.
Shining light on densely interwoven nerve fibres inside the brainDisentangling the complex nerve fibre network of the brain is becoming easily accessible with scattered light imaging (SLI): researchers in Delft, Jülich (Germany) and Stanford (USA) successfully combined light and X-ray scattering with MRI to discern nerve fibre trajectories, also in regions with highly entangled fibres. SLI revealed the trajectories at highest detail, while being significantly faster and cheaper than X-ray and MRI techniques. Such detailed mapping is essential for a better understanding of how nerve fibres are wired inside the brain.
Mark Vermeulen joined ImPhys as a MSc studentMark Vermeulen's Master end project consists of looking at T2Rho relaxation mapping MRI.
The hope is that this will eventually reduce the need for contrast agents in cardiac MRI. He is conducting his project in the MARS Lab under supervision of Chiara Coletti and Sebastian Weingärtner.
Enya Berrevoets joined ImPhys as PhD studentEnya Berrevoets recently started her PhD at the computational imaging group, where she will be supervised by Sjoerd Stallinga and Bernd Rieger. Her research will take place within the IMAGINE! (Innovative Microscopy and Guidance of cells In their Native Environment) consortium and will be focused on computational imaging solutions for visualising cells and subcellular structures in 3D and at high resolution.
In the spotlight
In the spotlight
Advanced microscopy to understand life and fight disease
In the NL-BI consortium, scientists from all Dutch academic research centres will together develop and integrate state-of-the-art microscopy with technologies and services in different nodes. This will enable access for all scientists to revolutionise fundamental insights into the building blocks of life, enable scientific breakthroughs, and advance applications towards society for overcoming life-threatening disease, including cancer, metabolic, cardiovascular, and neurodegenerative disorders.
Pushing the boundaries of ultrasound
Physicist David Maresca has received a Chan Zuckerberg Initiative Dynamic Imaging grant to develop a next-generation medical ultrasound tool. While state-of-the-art ultrasound imaging, known to most as a baby’s first picture, can show our anatomy and organs, the new tool will be able to zoom in much further, all the way down to the level of the cells in our body. Maresca: “Ultrasound is a safe but also affordable and widespread technology. If we can push the boundaries and make it more sensitive, it will potentially help a lot of people.”
Microscope shows researchers the way to proteins
Physicists from TU Delft, Daan Boltje and Jacob Hoogenboom have developed a 3-in-1 microscope where a light beam, electron beam and ion beam work together to precisely cut out specific slices from biological samples. These slices are indispensable for biomolecular research into new generations of medicines.
Spying on microscopic blood vessels in the heart and brain
Sebastian Weingärtner will use Magnetic Resonance Imaging (MRI) to exploit hydrogen atoms as microscopic spies to investigate the smallest blood vessels in the body. These ultra-small blood vessels are so fine that they evaded medical imaging so far, yet a better understanding of their features could be a transformative step towards better treatment of diseases like heart failure and dementia.
From light spots to supersharp images
Making detailed 3D images of proteins in living cells with a special light microscope, without damaging those cells. That is what Sjoerd Stallinga, winner of an ERC Advanced grant worth 2.3 million euros, wants to achieve. In order to do so he is going to scan samples nanometer by nanometer using a sophisticated 3D light pattern in an approach that requires extensive collaboration between different disciplines.
Spotlight on aggressive cancer cells
Metastases in cancer are often caused by a few abnormal cells. These behave more aggressively than the other cancer cells in a tumour. Miao-Ping Chien and Daan Brinks are working together, from two different universities, on a method to detect these cells. Their research has now been published in Nature Biomedical Engineering
How to find structurally different molecules before they disappear in the average?
Particle fusion for single molecule localization microscopy improves signal-to-noise ratio and overcomes underlabeling, but ignores structural heterogeneity or conformational variability. This study presents a-priori knowledge-free unsupervised classification of structurally different particles employing the Bhattacharya cost function as dissimilarity metric.
The impact of noise on Structured Illumination Microscopy image reconstructions
Super-resolution structured illumination microscopy (SIM) has become a widely used method for biological imaging. Standard reconstruction algorithms, however, are prone to generate noise-specific artifacts that limit their applicability for lower signal-to-noise data. Here we present a physically realistic noise model that explains the structured noise artifact, which we then use to motivate new complementary reconstruction approaches.
A new tool to understand the brain
How does our brain work? An international team of researchers, including lead author Daan Brinks of TU Delft, has taken another step towards answering that question. They have created a new tool that allows them to image electrical signals in brains with an unprecedented combination of precision, resolution, sensitivity, and depth.
Researchers make 3D image with light microscope
For the first time, Delft researchers have succeeded in making a three-dimensional image of a cellular component using light. The component in question is the nuclear pore complex: tunnels that facilitate traffic to and from the cell nucleus. Studying cell components in 3D can help to determine the cause of various diseases, among other things. The researchers have published their findings in Nature Communications.
Decoding movement intentions in the brain using ultrasound waves
While many techniques can image brain activity, this was the first time that a new technology, called functional ultrasound imaging, was used to detect motor planning deep within the brain. The team is now applying functional ultrasound decoding to more complicated motor control tasks. At ImPhys, Dr. Maresca is developing ultrasound technologies to image brain activity down to the cellular scale.