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Collaborations by design
Addressing the complex challenges of today and tomorrow requires many actors, perspectives and disciplines. But forming effective and mutually beneficial collaborations can be challenging. Designing with Delft aims to facilitate this process, bringing researchers and educators from the university together with innovators from organisations to identify common goals, define a shared vision and develop concrete plans for collaborations.
Paper published in Health Economics, Policy and Law on preferences in health treatment divestments
It is currently unknown which characteristics of healthcare interventions are considered important by citizens when making decisions about divestments. Therefore, this study aims to investigate the preferences of citizens of the Netherlands regarding the relative importance of attributes of healthcare interventions in the context of divestment.
Handling stress: using wearable technology to help people with PTSD
The obvious triggers of stress are all around us: pressing deadlines at work, children not sleeping through the night, a leaking roof. But sometimes it's smaller things, certain locations or specific times of day, that increase our stress levels. Understanding those triggers using wearable technology, with a focus on people who experience a lot of stress - people with PTSD - was the topic of Xueliang Li’s PhD research.
Gravity grant awarded to research on brain interactions
To understand how the brain works, we need to understand how each part, from neuron to brain region, interacts with the rest of the brain and with the outside world. Thanks to a grant of 21.9 million euros from the Gravity program, from the Ministry of Education, Culture and Science, a national consortium can now conduct further research into this.
From light spots to supersharp images
Making detailed 3D images of proteins in living cells with a special light microscope, without damaging those cells. That is what Sjoerd Stallinga, winner of an ERC Advanced grant worth 2.3 million euros, wants to achieve. In order to do so he is going to scan samples nanometer by nanometer using a sophisticated 3D light pattern in an approach that requires extensive collaboration between different disciplines.
Bacterial soundtracks revealed by graphene membrane
A of researchers from TU Delft , led by dr. Farbod Alijani, have managed to capture low-level noise of a single bacterium using graphene. Now, their research is published in Nature Nanotechnology.
Dutch Research Council Veni grant for Robin de Kruijff
The Dutch Research Council (NWO) has awarded a Veni grant to researcher Robin de Kruijff of the Reactor Institute Delft (RID) for her research on a new type of radionuclide generator which, among other things, can obviate the global bottleneck in cancer research. The new generator will, moreover, be the first recyclable one of its kind. “I hope that my new type of generator will ultimately make diagnostic treatments much more accessible and less dependent on a handful of reactors”, says De Kruijff.
Spotlight on aggressive cancer cells
Metastases in cancer are often caused by a few abnormal cells. These behave more aggressively than the other cancer cells in a tumour. Miao-Ping Chien and Daan Brinks are working together, from two different universities, on a method to detect these cells. Their research has now been published in Nature.
New Cas9 model maps DNA cutting behaviour for the first time
Researchers from the TU Delft have come up with a physical-based model that establishes a quantitative framework on how gene-editing with CRISPR-Cas9 works, and allows them to predict where, with what probability, and why targeting errors (off-targets) occur. This research, which has been published in Nature Communications, gives us a first detailed physical understanding of the mechanism behind the most important gene editing platform of today.
Cell unstuck: how a glue-like protein can make our cells move
An essential aspect of the cells in our body is their ability to move, to repair certain tissues or chase intruders, for example: but how do they do it? Scientists from TU Delft, AMOLF and Utrecht University reveal how glue-like proteins called crosslinkers could not only help to hold the whole cell together passively, but surprisingly cause the cell to move as well. The research is now published in PNAS.
ERC Proof of Concept Grant for Arjen Jakobi
Arjen Jakobi (Department of Bionanoscience) receives the ERC Proof of Concept Grant for his groundbreaking research on cryogenic electron microscopy (cryo-EM). "This grant will allow us to take our new CryoChip technique for high resolution images of protein molecules to the next level for the development of new drugs," says Jakobi.
Effectiveness of 2G and 3G has declined
At the request of the Dutch Ministry of Health, Welfare and Sport, researchers from TU Delft, UMC Utrecht and Populytics investigated the extent to which the various types of COVID certificates (coronatoegangsbewijs, CTB) can help to prevent the spread of COVID-19 in society. The 3G (vaccinated, recovered, tested) and 2G (vaccinated, recovered) rules are currently a lot less effective in curbing the spread of the virus than they were two months ago. A 1G policy (only people who have recently tested negative are given access) is much more effective. But, even if a 1G policy were to be introduced today, the reproduction number would not drop below 1.0.
Super-fast technique measures heme enzyme reaction as it happens
Researchers from TU Delft found an unexpected new enzyme intermediate at work in enzymes that contain heme, a cofactor that’s vital for many processes in our body such as the breaking down of toxins in the liver. The researchers used new, rapid techniques, which are less invasive than existing methods. The results, published in ACS Catalysis, increase our understanding of heme proteins and enzymes and how they can be engineered.
Out of the Blue #24: Clashing Disciplines in Healthcare - Richard Goossens
A design researcher and a doctor sit together for a coffee in a hospital café. They discuss and draw on a napkin what a joined education programme for designers and medical students could look like. What if doctors understood design for healthcare, and designers the healthcare world?
Out of the Blue #23: A Designer walks into a Hospital - Maaike Kleinsmann
How can design research improve our health, and is it better to design for prevention or for the cure? We kick off our triptych on Design & Health with Delft Design Professor Maaike Kleinsmann. Ianus and co-host Marc talk with her about working with healthcare professionals as a design researcher, what all this new remote-sensing health-tech for consumers means for personal health challenges and the issue of health data and privacy. And dealing with Strava-men in tight lycra suits.
New method predicts drug response of cancer patients
Researchers from Delft University of Technology and the Netherlands Cancer Institute (NKI) have developed an algorithm to predict patient response to anti-cancer drugs. This allows us to identify more rapidly if some drugs can have a positive effect on a specific patient, even for complicated medicines such as chemotherapies where response is typically hard to predict. This method is called TRANSACT and makes use of the wealth of data previously collected through research with cell lines.
Fitrim: Wheelchair power to the people
Just imagine that you just drove your wheelchair for half an hour over bumpy roads and some grassy spots, only to have your fitbit or smartphone activity tracker inform you that you took only 50 steps, burned virtually no calories and that you shouldn’t be such a couch potato. ‘There has to be a better way,’ Marit van Dijk thought. A seed grant from Delft Health Initiative and the TU Delft Sports Engineering Institute makes the difference.
Self-experimentation for long-lasting physical activity promotion in cardiac rehabilitation
A heart-attack may very well be the ultimate wake-up call when it comes to changing your lifestyle and behaviour. Even so, four years on most cardiac patients have relapsed to a very low fitness and physical activity level. Explorative self-experimentation, developed by Jos Kraal and colleagues, makes changing physical activity behaviour for cardiac patients more personal.
The formation of kidney stones on a microscale
Researchers from TU Delft developed a method to watch the formation of kidney stones on a microscale, in a so called microfluidic platform. By slightly adjusting the pH and the concentration of specific minerals, the formation could be slowed down or inhibited completely. The research is now published in Biomicrofluidics.
Healthy Start: Increasing opportunities for young people
Scanning a single protein, one amino acid at a time
Using nanopore DNA sequencing technology, researchers from TU Delft and the University of Illinois have managed to scan a single protein: by slowly moving a linearized protein through a tiny nanopore, one amino acid at the time, the researchers were able to read off electric currents that relate to the information content of the protein. The researchers published their proof-of-concept in Science today. The new single-molecule peptide reader marks a breakthrough in protein identification, and opens the way towards single-molecule protein sequencing and cataloguing the proteins inside a single cell.
Mechanism underlying the emergence of virus variants unravelled
An international consortium, led by Delft University of Technology and the University of North Carolina, has for the first time succeeded in probing the molecular origins of recombination in RNA viruses. Hiccups during the copying process of viruses cause recombination to take place: the exchange of segments of viral RNA.
Design for Deaf culture and health
Patients failing to take their medication in the prescribed manner is a widespread problem across society. But a combination of social barriers, discrimination and difficulty with written language mean that the Deaf community has a greater struggle. This medication non-adherence can be dangerous for patients, prolong sickness and strained healthcare systems. Ph.D. researcher Prangnat Chininthorn wanted to find ways to improve this and help Deaf people better manage their own health.
Mapping the brain motor cortex region in detail
In a major study funded by U.S Government, an international consortium of researchers successfully mapped the different types of brain cells in the motor cortex. Scientists from the Leiden University Medical Center (LUMC) and Delft University of Technology (TU Delft) contributed specific expertise to visualize the data.
Researchers unravel molecular replication process of covid-19
Is there a way to stop SARS-CoV-2-? An international consortium, led by biophysicist David Dulin at VU Amsterdam and in collaboration with Martin Depken from TU Delft, has investigated how to interfere with the viral genome-replication process at the molecular level.
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