Innovation is crucial to fulfil the potential of industrial biotechnology for sustainable production of fuels, chemicals, materials, food and feed. Similarly, scientific and technological advances in environmental biotechnology are needed to enable novel approaches to water purification, and ‘waste-to-product’ processes thus contributing to a circular economy. Increased fundamental knowledge encompassing enzymes, microorganisms and processes are essential for progress in this field. The Department of Biotechnology covers this research area and, based on new insights, selects, designs and tests new biobased catalysts, micro-organisms, and processes.
The department encompasses five research sections:
22 March 2023
The Protein Transition: unchaining a revolutionWith pioneering patents, leading start-ups, strong scientific research and the presence of industrial giants like DSM, the Netherlands has everything it needs to lead a revolution in the field of meat substitutes and cultured meat. Unfortunately, the legislation relating to these products is slowing things down and promising start-ups are moving abroad. Is our country at risk of falling behind?
21 December 2022
BEI Best MSc Graduate 2022: Raman van Wee!BEI Best MSc Graduate Awards 2022 Since 2020, Delft Bioengineering Institute (BEI) organizes a cross-campus competition for MSc students who performed remarkably well at their graduation projects in bioengineering. This year, nine very impressive theses were submitted. After a strenuous review and discussion, the jury finally agreed that Raman van Wee (MSc Nanobiology), Nastaran Barin (MSc Mechanical Engineering) and Juancito van Leeuwen (MSc Nanobiology and Biomedical Engineering) have delivered the most innovative, interdisciplinary bioengineering projects of 2022. On top of eternal fame, they will receive personal cash prizes of €1000, €500 and €250. 1. Raman van Wee (MSc Nanobiology) Thesis: Using DNA Nanotechnology and Fluorescence for Single-Molecule Protein Identification Supervisor: Chirlmin Joo (TNW/BN) Chirlmin Joo: “Raman is absolutely outstanding! He grasped the whole picture of the project in less than a month and was much motivated and capable to lead the project by making a grand plan and executing it promptly. Throughout his master’s project, he demonstrated original and independent thinking, which has helped revealing the potential of the new technology. It has also resulted in new methods in my group for protein labelling and single-molecule studies of DNA-tagged proteins, which will be essential for the next phase of the project. The quality and quantity of his data exceeded the expectation. He produced two research articles (one of them published in iScience) as a co-author as well as a review paper as a leading author.” 2. Nastaran Barin (MSc Mechanical Engineering) Thesis: 3D-Engineered Scaffolds to Study Primary Glioblastoma Microtube Formation and EGFR Expression Supervisors: Angelo Accardo (TU Delft), Pim French (Erasmus MC) Angelo Accardo: “The work performed by Nastaran is a perfect example demonstrating the added value of combining two different disciplines. Regardless of her engineering background, Nastaran showed immediately an innate predisposition also for the biological part of this study (cell culture, confocal imaging and advanced image data analysis tasks) which is a remarkable feat. The results of her MSc thesis were awarded with a final grade of 9/10. After obtaining her Master’s at TU Delft, she embarked in a PhD program at Erasmus MC in collaboration with TU Delft under my and Pim French’s supervision. Having a mechanical engineering background, undertaking a PhD in a medical center like Erasmus MC is the proof of how Nastaran can easily bridge these two environments, ways of thinking and required skill-sets. Her work has been recently published in Small, one of the most prestigious interdisciplinary journals in the field of bioengineering, and even featured the front cover.” 3. Juancito van Leeuwen (MSc Nanobiology and Biomedical Engineering) Thesis: Engineering of protein based phononic crystals for contrast-enhanced ultrasound imaging Supervisors: David Maresca (TNW/ImPhys), Valeria Garbin (TNW/ChemE) David Maresca: “Juancito has achieved and sustained an excellent level of research in the field of Biomolecular Ultrasound over the year that he has spent in my laboratory and that of Valeria Garbin. He is truly one of the most talented and hardworking master students I have worked with so far. In 2021, Valeria and I were awarded a BioDate MSc project entitled “Droplet‐based self‐assembly of gas vesicles for novel acoustic biosensors”, and in September, Juancito joined my research group as a MEP student to pursue this research project. Juancito’s research combined aspects of ultrasound imaging physics, molecular engineering, and microfluidics. It was truly an interdisciplinary research endeavour. He demonstrated that the assembly of protein-based ultrasound contrast agents could boost their acoustic scattering by fourfold. Based on this finding, he designed and tested microfluidic chips for the high-throughput fabrication of echogenic protein assemblies, that could ultimately serve as long circulating ultrasound contrast agents for neuroimaging. His research required to work proficiently with ultrasound imaging scanners, genetically encoded proteins, cryo-EM microscopes, microfluidic systems and phase contrast microscopes in multiple labs across campus. He defended his thesis for a double degree MSc and graduated Cum Laude.”
30 November 2022
NWO Open Technology funding to produce a versatile acid sustainablyThe NWO has awarded over 5.3 million euros to six projects through the Open Technology Programme, including the research of Ludovic Jourdin to make products from CO2 and renewable electricity, based on a versatile acid. Apart from the NWO funding, companies and other organisations involved invest 1.1 million euros into the projects.
28 May 2020
Awards for three researchers of ASIt's raining awards at the Faculty of Applied Sciences. No less than three researchers have been rewarded with various prizes over the past period. They are Ad van Well, Arthur Gorter de Vries and Jasmijn Hassing. Together with colleagues from 3mE, Ad van Well (Radiation Science & Technology) received the Vanadium Award for the best scientific article of 2019 in the fiel of vanadium research . The award is presented by the Institute of Materials, Minerals and Mining (IOM3) in Great Britain. The article stems from the HTM/NWO Nano-steel project, in which Ad van Well and his colleagues, especially PhD candidate Chrysoula Ioannidou, are researching a new type of steel that is both strong and malleable: pure ferrite reinforced with nanoparticles of vanadium carbide. Ex-researcher A rthur Gorter de Vries (Biotechnology) received the Westerdijk Award for the best dissertation of the year in the category Environmental & Applied Microbiology . This award is presented by the Royal Dutch Society for Microbiology (KNVM) and the Dutch Society for Medical Microbiology (NVMM). Gorter de Vries was frequently in the news before his promotion, among other things because he witnessed the emergence of a new gene in the lab and because of his discovery that all pilsner yeasts, the famous microorganisms that brewers produce hundreds of billions of litres of lager and other lager beers with every year, were created some 500 years ago in a one-off encounter between two types of yeast . Jasmijn Hassing, like Gorter de Vries from the group of Jean-Marc Daran (Biotechnology), received the Kiem Award. This prize is also awarded by the KNVM/NVMM, and is intended for excellent papers in which starting young microbiologists are the first authors. In order to qualify, the article must have been published in an internationally renowned journal in the past year. Hassing was awarded the prize for a paper on the production of 2-phenylethanol using yeast. 2-phenylethanol is an organic, aromatic compound that smells like roses and is widely used in the food and cosmetics industries.
14 May 2020
How copper can damage a cellCopper is important for many processes in our body. Among other things, it supports the production of red blood cells, metabolism, and the formation of connective tissue and bones. Copper is also known to play a role in diseases such as cancer, diabetes and Alzheimer's disease. Unfortunately, we do not yet know exactly what that role entails. Researchers from Delft University of Technology and the Polish Academy of Sciences have now discovered a new piece of the puzzle. In order to be able to do its work, copper binds to different types of proteins in the cell. And although the complexes that are formed in this process are not harmful in themselves, temporary 'intermediate forms' appear to arise during the binding, which can lead to damage to the cell. The results of the research have been published in Angewandte Chemie.
30 April 2020