Innovation is crucial to fulfil the potential of industrial biotechnology for sustainable production of fuels, chemicals, materials, food and feed. Similarly, scientific and technological advances in environmental biotechnology are needed to enable novel approaches to water purification, and ‘waste-to-product’ processes thus contributing to a circular economy. Increased fundamental knowledge encompassing enzymes, microorganisms and processes are essential for progress in this field. The Department of Biotechnology covers this research area and, based on new insights, selects, designs and tests new biobased catalysts, micro-organisms, and processes.
The department encompasses five research sections:
15 April 2022
National Growth Fund finances Cellular AgricultureThe National Growth Fund of the Dutch government grants conditional funding of 60 million euros to the Cellular Agriculture consortium, whose goal is to produce and promote protein-rich food from cultivated cells. The TU Delft is one of the founders of the consortium, with Marcel Ottens as initiator of the line of research. The TU Delft, together with the companies PlanetBio, DSM, Meatable, CE Delft and others, forms a hub in Delft for this new field of work.
24 February 2022
Mark van Loosdrecht wins Novozymes Prize for 25 years of revolutionary wastewater treatmentThe development of new technologies for biological wastewater treatment is turning our view of sludge upside down. Microbiologist Mark van Loosdrecht receives the 2022 Novozymes Prize for his pioneering work in copying and reusing nature’s mechanisms in wastewater treatment and resource recovery. Van Loosdrecht: “Treating wastewater will become good business in the future.”
23 December 2021
Super-fast technique measures heme enzyme reaction as it happensResearchers from TU Delft found an unexpected new enzyme intermediate at work in enzymes that contain heme, a cofactor that’s vital for many processes in our body such as the breaking down of toxins in the liver. The researchers used new, rapid techniques, which are less invasive than existing methods. The results, published in ACS Catalysis, increase our understanding of heme proteins and enzymes and how they can be engineered.
22 March 2023
The Protein Transition: unchaining a revolutionWith pioneering patents, leading start-ups, strong scientific research and the presence of industrial giants like DSM, the Netherlands has everything it needs to lead a revolution in the field of meat substitutes and cultured meat. Unfortunately, the legislation relating to these products is slowing things down and promising start-ups are moving abroad. Is our country at risk of falling behind?
21 December 2022
BEI Best MSc Graduate 2022: Raman van Wee!BEI Best MSc Graduate Awards 2022 Since 2020, Delft Bioengineering Institute (BEI) organizes a cross-campus competition for MSc students who performed remarkably well at their graduation projects in bioengineering. This year, nine very impressive theses were submitted. After a strenuous review and discussion, the jury finally agreed that Raman van Wee (MSc Nanobiology), Nastaran Barin (MSc Mechanical Engineering) and Juancito van Leeuwen (MSc Nanobiology and Biomedical Engineering) have delivered the most innovative, interdisciplinary bioengineering projects of 2022. On top of eternal fame, they will receive personal cash prizes of €1000, €500 and €250. 1. Raman van Wee (MSc Nanobiology) Thesis: Using DNA Nanotechnology and Fluorescence for Single-Molecule Protein Identification Supervisor: Chirlmin Joo (TNW/BN) Chirlmin Joo: “Raman is absolutely outstanding! He grasped the whole picture of the project in less than a month and was much motivated and capable to lead the project by making a grand plan and executing it promptly. Throughout his master’s project, he demonstrated original and independent thinking, which has helped revealing the potential of the new technology. It has also resulted in new methods in my group for protein labelling and single-molecule studies of DNA-tagged proteins, which will be essential for the next phase of the project. The quality and quantity of his data exceeded the expectation. He produced two research articles (one of them published in iScience) as a co-author as well as a review paper as a leading author.” 2. Nastaran Barin (MSc Mechanical Engineering) Thesis: 3D-Engineered Scaffolds to Study Primary Glioblastoma Microtube Formation and EGFR Expression Supervisors: Angelo Accardo (TU Delft), Pim French (Erasmus MC) Angelo Accardo: “The work performed by Nastaran is a perfect example demonstrating the added value of combining two different disciplines. Regardless of her engineering background, Nastaran showed immediately an innate predisposition also for the biological part of this study (cell culture, confocal imaging and advanced image data analysis tasks) which is a remarkable feat. The results of her MSc thesis were awarded with a final grade of 9/10. After obtaining her Master’s at TU Delft, she embarked in a PhD program at Erasmus MC in collaboration with TU Delft under my and Pim French’s supervision. Having a mechanical engineering background, undertaking a PhD in a medical center like Erasmus MC is the proof of how Nastaran can easily bridge these two environments, ways of thinking and required skill-sets. Her work has been recently published in Small, one of the most prestigious interdisciplinary journals in the field of bioengineering, and even featured the front cover.” 3. Juancito van Leeuwen (MSc Nanobiology and Biomedical Engineering) Thesis: Engineering of protein based phononic crystals for contrast-enhanced ultrasound imaging Supervisors: David Maresca (TNW/ImPhys), Valeria Garbin (TNW/ChemE) David Maresca: “Juancito has achieved and sustained an excellent level of research in the field of Biomolecular Ultrasound over the year that he has spent in my laboratory and that of Valeria Garbin. He is truly one of the most talented and hardworking master students I have worked with so far. In 2021, Valeria and I were awarded a BioDate MSc project entitled “Droplet‐based self‐assembly of gas vesicles for novel acoustic biosensors”, and in September, Juancito joined my research group as a MEP student to pursue this research project. Juancito’s research combined aspects of ultrasound imaging physics, molecular engineering, and microfluidics. It was truly an interdisciplinary research endeavour. He demonstrated that the assembly of protein-based ultrasound contrast agents could boost their acoustic scattering by fourfold. Based on this finding, he designed and tested microfluidic chips for the high-throughput fabrication of echogenic protein assemblies, that could ultimately serve as long circulating ultrasound contrast agents for neuroimaging. His research required to work proficiently with ultrasound imaging scanners, genetically encoded proteins, cryo-EM microscopes, microfluidic systems and phase contrast microscopes in multiple labs across campus. He defended his thesis for a double degree MSc and graduated Cum Laude.”
30 November 2022