Biotechnology

Innovation is crucial to fulfil the potential of industrial biotechnology for sustainable production of fuels, chemicals, materials, food and feed. Similarly, scientific and technological advances in environmental biotechnology are needed to enable novel approaches to water purification, and ‘waste-to-product’ processes thus contributing to a circular economy. Increased fundamental knowledge encompassing enzymes, microorganisms and processes are essential for progress in this field. The Department of Biotechnology covers this research area and, based on new insights, selects, designs and tests new biobased catalysts, micro-organisms, and processes.

The department encompasses five research sections:

News

05 July 2018

Delft Advanced Biorenewables attracts capital and commercial director for scale-up phase

Serial entrepreneur Jan Willem Klerkx participates and joins start-up Delft Advanced Biorenewables (DAB), that developed a unique technology to produce biochemicals and biofuels in a cheaper and more efficient way. Klerkx becomes shareholder and joins the management. Details about the investment are not published. DAB , a spin-off of TU Delft, has gone through an extensive development trajectory in the last four years and is now in the phase of scaling up, in which Klerkx will play an important role. Using his knowledge and experience, the serial entrepreneur regularly joins technology start-ups to strengthen them in the field of management and sales. Previously, he invested in the start-up Scyfer (artificial intelligence), which was taken over by Qualcomm last year. With DAB, Klerkx now focuses on sustainable energy. "I had the idea for a while to spend my time and energy on supporting the circular economy. What DAB does - reducing the production costs of biofuels and biochemicals - is an important contribution to this. The technology and scientific team of DAB are world-class. I look forward to making the company stronger commercially with my experience." DAB Corporate Movie from DelftAB on Vimeo . Director of DAB, Kirsten Steinbusch, is pleased with the arrival of Klerkx. "Jan Willem has proven to be able to make a difference in knowledge based start-ups. We can use his commercial skills and strategy to enable DAB to grow further." TU Delft also has an interest in DAB through ‘ Delft Enterprises ’. Director Paul Althuis: "TU Delft is committed to work on a sustainable future. That is why it is important that our scientists’ groundbreaking research also reaches the market. That is why we invest in promising technological innovations, such as those of DAB." DAB was founded in 2012 with the conviction that in the near future there will be an increasing demand for advanced fuels and chemicals that are produced from biomass. To make biobased an attractive alternative, the production process should become cost effective and scalable. DAB has developed a unique separation and reactor technology to convert organic material into biofuels and biological chemicals in a single process step, resulting in both lower costs and simplified production. DAB works closely with TU Delft and the Bioprocess Pilot Facility (BPF) to scale up the technology. The joint research project is subsidized by the Ministry of Economic Affairs, national regulations for Ministry of Economic Affairs subsidies and the ‘Top Sector Energie’ carried out by the Dutch Enterprise Agency (RVO). For more information, please contact Kirsten Steinbusch - Managing Director DAB

News

25 November 2021

BEI Best MSc Graduate 2021: Alicia Rodríguez Molina!

BEI Best MSc Graduate Awards 2021 Since 2020, Delft Bioengineering Institute (BEI) organizes a cross-campus competition for MSc students who performed remarkably well at their graduation projects in bioengineering. This year, sixteen very impressive theses were submitted. After a strenuous review and discussion, the jury finally agreed that Alicia Rodríguez Molina (MSc Life Science & Technology), Akash Singh (MSc Computer Science) and Jette Bloemberg (MSc Mechanical Engineering) have delivered the most innovative, interdisciplinary bioengineering projects of 2021. On top of eternal fame, they will receive personal cash prizes of €1000, €500 and €250. 1. Alicia Rodríguez Molina (MSc Life Science & Technology) Thesis: "TPR-CHAT is a caspase-like protease that forms a complex with the CRISPR-Cas type III-E endoribonuclease effector gRAMP” Daily supervisor: Sam van Beljouw (Applied Sciences, Bionanoscience) Thesis Committee: Stan Brouns (AS/BN), Peter-Leon Hagedoorn (AS/Biotechnology), Chirlmin Joo (AS/BN) “Alicia has made large contributions to our research discovering a new CRISPR-Cas system with potentially profound implications and new applications. She has been responsible for the major discovery that links a protease (protein cleaving enzyme) to CRISPR-Cas for the first time. The protein complex she identified was named Craspase and can likely trigger cell suicide in bacteria to protect bacteria from virus infection. We anticipate that Craspase can be converted to a tool for applications in molecular diagnostics, targeted knockdown of gene expression and biomolecule activation or deactivation in cells. A patent was also filled to protect some of these ideas. Importantly, her findings were included in a paper published in Science August 26 (attached) on which she was third author.” 2. Akash Singh (MSc Computer Science) Thesis: “Unsupervised Manifold Alignment with TopoGAN” Thesis Committee: Marcel Reinders (EWI/Pattern Recognition and Bioinformatics), Christoph Lofi (EWI/Web Information Systems), Ahmed Mahfouz (EWI/PRB and LUMC/Radiology), Tamim Abdelaal (LUMC/Radiology) “In his thesis, Akash developed TopoGAN, a deep learning method to solve the challenging task of integrating single cell datasets with no matching samples (i.e. cells) or features. Akash’s thesis proposes multiple innovative ideas to address this challenge. First, Akash showed that Topological Autoencoders can capture the heterogeneity of single cell data better than current approaches such as (variational autoencoders, tSNE and UMAP). This on its own is a significant contribution to the field. Second, Akash proposed an approach to tackle the instability of GAN methods in the task of manifold alignment, which can be generally applied in other fields of machine learning. Third, in evaluating the performance of his method, Akash showed that current strategies have severe shortcomings and should as such be revised to faithfully reflect the performance of different methods.” 3. Jette Bloemberg (MSc Mechanical Engineering) Thesis: “MRI-Ready Actuation System for a Self-Propelling Needle” Supervisors: Fabian Trauzettel (3mE/Biomechanical Engineering), Dimitra Dodou (3mE/BmechE), Paul Breedveld (3mE/BmechE) Thesis Committee: Paul Breedveld (3mE/BmechE), Fabian Trauzettel (3mE/BmechE), Dimitra Dodou (3mE/BmechE), Matthijs Langelaar (3mE/Precision and Microsystems Engineering), Jovana Jovanova (3mE/MTT) “Jette did a very interesting research into a new kind of self-propelled steerable needle for prostate interventions under MRI. She developed a perfectly working prototype, bio-inspired on the anatomy of parasitic wasps. (…) Based on a past PhD project in which we developed novel, self-propelling needles based on the ovipositor-anatomy of parasitic wasps, Jette brought this research to an entirely new level. In her project we wanted to evaluate ovipositor-inspired needles on human prostate tissue under MRI. This means that the design should not contain any metallic parts that react on the powerful magnetic MRI-field. To solve this issue, Jette designed an entirely novel manually-driven propulsion mechanism that she printed from plastic on Formlabs and Ulitimaker 3D-printers, thereby gaining a lot of know-how on how to design complex mechanisms with tight tolerances using 3D printers. Driven by her novel propulsion mechanism, Jette designed a very thin (Ø0,81mm) ovipositor needle composed out of six individually moveable NiTi rods. For the experiments in human prostate tissue, Jette set up a very close collaboration with a well-known urology group at the Amsterdam University Medical Center (AUMC), headed by Dr. Daniel Martijn de Bruin. Jette organised many meetings with this group, arranging human prostate tissue, and using an MRI-laboratory scanner at the AUMC for her experiments. As the space within this MRI-scanner was limited, she also developed a special experimental facility in which the tissue could be stored and moved with near zero friction.”
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