Innovation is crucial to fulfil the potential of industrial biotechnology for sustainable production of fuels, chemicals, materials, food and feed. Similarly, scientific and technological advances in environmental biotechnology are needed to enable novel approaches to water purification, and ‘waste-to-product’ processes thus contributing to a circular economy. Increased fundamental knowledge encompassing enzymes, microorganisms and processes are essential for progress in this field. The Department of Biotechnology covers this research area and, based on new insights, selects, designs and tests new biobased catalysts, micro-organisms, and processes.
The department encompasses five research sections:
05 July 2018
Delft Advanced Biorenewables attracts capital and commercial director for scale-up phaseSerial entrepreneur Jan Willem Klerkx participates and joins start-up Delft Advanced Biorenewables (DAB), that developed a unique technology to produce biochemicals and biofuels in a cheaper and more efficient way. Klerkx becomes shareholder and joins the management. Details about the investment are not published. DAB , a spin-off of TU Delft, has gone through an extensive development trajectory in the last four years and is now in the phase of scaling up, in which Klerkx will play an important role. Using his knowledge and experience, the serial entrepreneur regularly joins technology start-ups to strengthen them in the field of management and sales. Previously, he invested in the start-up Scyfer (artificial intelligence), which was taken over by Qualcomm last year. With DAB, Klerkx now focuses on sustainable energy. "I had the idea for a while to spend my time and energy on supporting the circular economy. What DAB does - reducing the production costs of biofuels and biochemicals - is an important contribution to this. The technology and scientific team of DAB are world-class. I look forward to making the company stronger commercially with my experience." DAB Corporate Movie from DelftAB on Vimeo . Director of DAB, Kirsten Steinbusch, is pleased with the arrival of Klerkx. "Jan Willem has proven to be able to make a difference in knowledge based start-ups. We can use his commercial skills and strategy to enable DAB to grow further." TU Delft also has an interest in DAB through ‘ Delft Enterprises ’. Director Paul Althuis: "TU Delft is committed to work on a sustainable future. That is why it is important that our scientists’ groundbreaking research also reaches the market. That is why we invest in promising technological innovations, such as those of DAB." DAB was founded in 2012 with the conviction that in the near future there will be an increasing demand for advanced fuels and chemicals that are produced from biomass. To make biobased an attractive alternative, the production process should become cost effective and scalable. DAB has developed a unique separation and reactor technology to convert organic material into biofuels and biological chemicals in a single process step, resulting in both lower costs and simplified production. DAB works closely with TU Delft and the Bioprocess Pilot Facility (BPF) to scale up the technology. The joint research project is subsidized by the Ministry of Economic Affairs, national regulations for Ministry of Economic Affairs subsidies and the ‘Top Sector Energie’ carried out by the Dutch Enterprise Agency (RVO). For more information, please contact Kirsten Steinbusch - Managing Director DAB
07 June 2018
Marcel Ottens’ group to participate in new International Training NetworkAs part of a large European biopharmaceutical consortium, the research group of Marcel Ottens will participate in a 4M€ Marie Curie International Training Network (ITN).
24 May 2018
Jack Pronk receives two awardsThe past weeks, Jack Pronk received two prizes. He was awarded the International Metabolic Engineering Award by the International Metabolic Engineering Society. In addition, he received the ‘Zilveren Zandloper’ (Silver Hourglass), an educational prize, during the Dutch Biotechnological Congress 2018 on 22 May.
14 May 2020
How copper can damage a cellCopper is important for many processes in our body. Among other things, it supports the production of red blood cells, metabolism, and the formation of connective tissue and bones. Copper is also known to play a role in diseases such as cancer, diabetes and Alzheimer's disease. Unfortunately, we do not yet know exactly what that role entails. Researchers from Delft University of Technology and the Polish Academy of Sciences have now discovered a new piece of the puzzle. In order to be able to do its work, copper binds to different types of proteins in the cell. And although the complexes that are formed in this process are not harmful in themselves, temporary 'intermediate forms' appear to arise during the binding, which can lead to damage to the cell. The results of the research have been published in Angewandte Chemie.
30 April 2020
Investment of 14 million for better use of micro-organismsMicroorganisms can perform many processes useful to mankind, such as converting milk to cheese, keeping human and animal intestines healthy, and cleaning our water and environment. Together with Wageningen University & Research and Delft University of Technology, the Dutch Research Council (NWO) will invest almost 25 million euros in a research facility for investigating mixed microbial communities and their application. The research facility – called UNLOCK (UNLOCKing Microbial Diversity for Society) - consists of equipment and human resources that will be used to gather knowledge on micro-organisms effectively. Team-players Micro-organisms are natural team-players. They are essential for human health via the intestinal microbiome, and for processes like waste water treatment, soil fertilization for plant growth, and food preparation such as cheese or beer through fermentation. However, even though natural and man-made ecosystems are characterized by an enormous microbial diversity, research on microbial communities and their application in biotechnological processes historically has been conducted with a very limited number of strains isolated from these ecosystems. We are currently using no more than 1 per cent of the microbiological potential available in nature Ecosystem Besides that, research on micro-organisms usually focuses on a limited number of specific strains of organisms, while in nature micro-organisms always operate in ecosystems consisting of different species. ‘You could compare it to building a house’, says Robbert Kleerebezem, who is the Delft scientist involved in the project. ‘To build one, you need different experts, like masons, roofers, electricians and plumbers. You can pick out any one of them, and study what they are doing, but that won’t tell you anything about what the resulting house will look like.’ Eagerly awaited Wageningen and Delft have launched the new research facility UNLOCK to study mixed microbial cultures extensively. Various sub-areas of research will be integrated through UNLOCK. This development has been eagerly awaited by researchers studying mixed microbial communities. This integration will make significant scientific and societal breakthroughs possible. NWO's approval will make a 14.5 million euro funding available for the next decade, of which a third will go to TU Delft. Automated cultivation of ecosystems "In Delft we will be working on making automated systems in which we can cultivate ecosystems of micro-organisms in mixed compositions, and monitor them’, says Kleerebezem. ‘This makes UNLOCK a unique facility, because we will be able to do comparative studies on a large scale and in an efficient manner, in order to gain important insights into the interactions between micro-organisms’. New persepectives A total of 24.8 million euros will be invested in UNLOCK. Lead petitioner, Prof. Hauke Smidt is delighted with the approval. ‘This is fantastic. UNLOCK opens up entirely new perspectives for the discovery of new micro-organisms and ground-breaking research on mixed microbial communities’. UNLOCKing Microbial Diversity for Society In UNLOCK, Wageningen and Delft have joined forces towards full integration of all relevant fields of expertise in four complementary platforms: · The Biodiscovery platform (WUR-Microbiology) allows its users to discover and characterize new micro-organisms. In addition, there is a processing unit that allows for fully automated unlocking of biological samples for biomolecular analysis. · The Modular bioreactor platform (WUR-Environmental Technology) facilitates research for sustainable solutions to environmental issues, such as the degradation of (micro) pollutants, sustainable energy generation and reclaiming resources from complex waste streams. · With the Parallel Bioreactor platform (TU Delft -Biotechnology), users can simultaneously conduct dozens of experiments in bioreactors for comparative analysis on how process variables affect system development. · The FAIR data platform (WUR-Systems & Synthetic Biology) takes care of the storage, processing and interpretation of large quantities of data flowing from the experimental systems in a cloud-based infrastructure based on the FAIR principles (Findable, Accessible, Interoperable, Reusable). Large-scale Scientific Infrastructure NWO has allocated a total of 93 million euros to seven projects. The Ministry of Culture and Education makes funds available to NWO for the National Roadmap for a Large-scale Scientific Infrastructure. These funds enable the building and overhaul of essential research infrastructures. The awarded scientific infrastructures are of critical importance to innovative scientific research, and as a stimulus for economic and societal innovations across all scientific disciplines. Robbert Kleerebezem +31 15 2781091 email@example.com
17 April 2020